Home    eJManager.com Add Your Journal   |    Follow on Twitter   |    Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article

Natl J Integr Res Med. 2016; 7(1): 37-40


Comparison Of ER-Positive Versus ER-Negative In Breast Cancer Women And Invasive Ductal Carcinoma In The West Of Iran: A Direct Correlation With Vascular Invasion

Mehrdad Payandeh*, Masoud Sadeghi**, Edris Sadeghi***, Seyed-Hamid Madani****.

Abstract
Background & Objective: ER expression is the main indicator of potential responses to endocrine therapy, and approximately 70% of human breast cancers are hormone-dependent and ER-positive. The aim of the study is to evaluate the correlation between risk factors with ER status in breast cancer patients in the West of Iran. Methodology: In a retrospective study, 260 breast cancer women were included invasive ductal carcinoma our Clinic. A sufficient sample size was selected from any patient, and the slides were stained by hematoxylin and eosin (H & E) method. Estrogen receptor (ER) and progesterone receptor (PR) positivity were defined as ≥10% positive tumor cells with nuclear staining. Chi-square test and T-test were used to analyze the significance of correlation between the expression of ER and other parameters. Results: The patients were divided into two groups (156 patients with ER-positive group and 104 patients with ER-negative group). There was a significant difference between histological grade, nuclear grade, lymph node metastasis, tumor size and vascular invasion and also tumor markers of HER2, PR, P53 expression with ER status. Based on binary logistic regression analysis, in patients with ER-positive, more patients had vascular invasion and PR-positive, but P53 was negative. Conclusion: There was a direct correlation between vascular invasion and PR, with ER status and a reverse correlation between p53 with ER status. [Sadeghi M NJIRM 2016; 7 (1): 37-40]

Key words: Breast cancer, Estrogen receptor, Vascular invasion, P53



Share this Article




ScopeMed Home
Follow ScopeMed on Twitter
Article Tools
Job Opportunities/Service Offers
eJManager OJMS
eJPort Journal Hosting
About ScopeMed
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Service of eJManager LLC Publishing for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons