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Natl J Integr Res Med. 2016; 7(1): 37-40

Comparison Of ER-Positive Versus ER-Negative In Breast Cancer Women And Invasive Ductal Carcinoma In The West Of Iran: A Direct Correlation With Vascular Invasion

Mehrdad Payandeh*, Masoud Sadeghi**, Edris Sadeghi***, Seyed-Hamid Madani****.

Background & Objective: ER expression is the main indicator of potential responses to endocrine therapy, and approximately 70% of human breast cancers are hormone-dependent and ER-positive. The aim of the study is to evaluate the correlation between risk factors with ER status in breast cancer patients in the West of Iran. Methodology: In a retrospective study, 260 breast cancer women were included invasive ductal carcinoma our Clinic. A sufficient sample size was selected from any patient, and the slides were stained by hematoxylin and eosin (H & E) method. Estrogen receptor (ER) and progesterone receptor (PR) positivity were defined as ≥10% positive tumor cells with nuclear staining. Chi-square test and T-test were used to analyze the significance of correlation between the expression of ER and other parameters. Results: The patients were divided into two groups (156 patients with ER-positive group and 104 patients with ER-negative group). There was a significant difference between histological grade, nuclear grade, lymph node metastasis, tumor size and vascular invasion and also tumor markers of HER2, PR, P53 expression with ER status. Based on binary logistic regression analysis, in patients with ER-positive, more patients had vascular invasion and PR-positive, but P53 was negative. Conclusion: There was a direct correlation between vascular invasion and PR, with ER status and a reverse correlation between p53 with ER status. [Sadeghi M NJIRM 2016; 7 (1): 37-40]

Key words: Breast cancer, Estrogen receptor, Vascular invasion, P53

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