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Original Article

IAJPR. 2014; 4(11): 5185-5192


HEPATOPROTECTIVE ACTIVITY OF LEAVES EXTRACTS OF CARISSA CARANDAS LINN

Pooja Bhati, Ajay Shukla*, Maya Sharma, Pramod mourya.

Abstract
The Hepatoprotective activity of leaves of Carissa carandas linn against carbon tetra chloride induced hepatotoxicity in albino rats was determined. The leaves were collected and dried under shade followed by crushing. The extraction of crushed powder involve the Maceration by using methanol and acetone (w/v 1:3) solvent and concentrated to dry mass by using rotary vacuum evaporator. Dark green waxy residues (leaves) were collected separately. The different parameter of evaluation were taken such as histopathological studies, Total Bilirubin, Direct Bilirubin, SGPT and SGOT etc. The Liver section of animal which was treated with methanol and acetone (w/v 1:3) extract clearly shows the normal hepatic cells and compared with Silymarin treated group of animals. The result suggests that the methonolic extract of leaves of Carissa carandas linn possess a significant role as hepatoprotective activity.

Key words: Carissa Carandas, Hepatoprotective, Carbon Tetra Chloride.


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