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Characterization of lymphocyte Infiltration in Molar pregnancies

Haider Fasial; jabbar salman; Manar Mustafa; Haleema salman.

Abstract
Summary:
Background: In normal pregnancy around 30% of stromal cells in decidualised endometrium are leucocytes, lymphocyte subtypes may play a role in the pathogenesis of molar pregnancies.
Objective: To investigate the pattern of infiltrating lymphocytes in paraffin embedded tissue sections obtained from molar pregnancies.
Materials and methods: This study included thirty-five archived paraffin-embedded samples of molar pregnancies; divided into 16 incomplete and 19 complete hydatid mole. Then dual immunofluorescence staining was used for phenotyping of lymphocytic infiltrate (CD3- CD19) and (CD4-CD8). Independent sample t-test was used to compare the mean cell counts between different study groups.
Results: There is higher T cells (CD3) infiltrate in complete hydatid mole than normal placental tissue (p=0.003) and not significant with incomplete hydatid mole (p=0.089). Plasma cells (CD19) were higher in both complete hydatid mole CHM (p=0.012) and incomplete hydatid mole iCHM (p=0.013). Cytotoxic cells (CD8) were none significant in all groups while Helper cells (CD4) were significantly higher in CHM (p=0.017) and iCHM (p=0.025).
Conclusions: The higher tissue infiltration with plasma cells and helper cells in both CHM and iCHM highlight the importance of these cells in molar pregnancy pathogenesis.

Key words: Hydatid mole;lymphocytes infiltration;complete hydatid mole (CHM);incomplete hydatid mole (iCHM)


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