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A study on dichlorvos induced hematology, clinical biochemistry and reproductive abnormalities in male albino rats.

Onyinyechukwu Ada Agina; Valentine Uneojo Omoja; Samuel Okezie Ekere; Samuel Odo; Benson Chukwunonso Agina.

Abstract
Aim/Background: Dichlorvos (Otapiapia®) is a locally formulated unspecified insecticide applied indiscriminately as a household repellant. It is used as an acaricide, rodenticide and botacide. This study evaluated the effect of oral administration of this dichlorvos on the hematology, serum biochemistry and cauda epididymal sperm reserve of male albino rats. Methods: Forty male albino rats were randomly assigned in to four groups designated A, B, C and D in galvanized cages. Groups A, B and C were dosed orally using orogastric cannula with 4, 2, and 1 mg/kg of otapiapia® respectively, daily for 28 days while group D received 10 ml/kg distilled water, and served as the control. All hematological, serum biochemistry and cauda epididymal sperm (CESR) analyses were done following standard procedures. Results: Significant (P < 0.05) differences were recorded in all the hematological and serum biochemistry parameters and cauda epididymal sperm reserve except in the serum ALP and creatinine values. Conclusion: Oral administration of dichlorvos (otapiapia®) as used in this study led to anemia, severe leukocytosis, hyperproteinemia, hyperglobulinemia, hypocholesterolemia, hyperglycemia and decreased epididymal sperm reserve.

Key words: Hematology;Clinical biochemistry;Reproduction;Male albino rats;Dichlorvos


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