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Role of anticardiolipin antibodies in bad obstetric history detected by ELISA test in a tertiary care centre

THERESE MARY DHASON; EUPHRASIA LATHA JAIRAJ; RAJESWARI SANKARALINGAM; BHUVANESH MAHENDREN; BALAJI CHILUKURI; SIVAKUMAR VENGUDUSAMY; MYTHILI SEETHARAMAN.

Abstract
Background: Antiphospholipid syndrome (APS) is one of the causes of recurrent abortions and intrauterine death among pregnant women. This study was undertaken to find out the association between bad obstetric history (BOH) and anticardiolipin (aCL) antibody. Material and Methods: Blood samples were collected from women with BOH referred (recurrent abortion, intrauterine death, PIH) to a Tertiary Care Center in Chennai, Tamil Nadu. Blood samples from 100 pregnant women with BOH and 110 healthy pregnant women were collected and tested for the presence of aCL antibody by ELISA Method. Results: Among the 100 patients tested 21 (21%) were aCL positive; IgG was positive in 16 (76.19%) patients and IgM was positive in 5(23.80%) patients. Anticordiolipin antibody (aCL) positivity in BOH was statistically significant (p .0048) when compared to healthy pregnant women. There was a positive correlation (p 0.005) between IgG and BOH. The antibody titer was high in 12 (57.14%) and moderate in 6 (28.57%). Among the controls 8(7.2%) were aCL positive.
Conclusion: Screening of patients with BOH for aCL by ELISA will reduce foetal morbidity and mortality as there is a significant association between high, moderate titers of aCL, (IgG) and BOH.

Key words: Antiphospholipid syndrome;Anticordiolipin Elisa;Bad Obstetric History


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