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Sokoto J. Vet. Sci.. 2017; 15(1): 49-56


Comparative effects of dexamethasone on placental and foetal organ weights and some linear body measurements in Yankasa sheep and Sahel goats

D Yahi; NA Ojo; GD Mshelia; VA Maina.

Abstract
Dexamethasone is a potent synthetic glucocorticoid use in veterinary and human medicine. However, it causes intra uterine growth restriction (IUGR) and decreases birth weights in some animal species and humans, although each species respond differently. This study investigated the effects of dexamethasone on placental weights and some foetal parameters in Yankasa sheep and Sahel goats with known average gestational length of 148.35 ± 1.50 days and 148.33 ± 1.58 days respectively. Ten adult Sahel goats comprising 8 does and 2 bucks and 10 Yankasa Sheep comprising of 8 ewes and 2 rams were used for this study. Pregnancies were achieved by natural mating after synchronization. Repeated dexamethasone injections were intramuscularly given at 0.25mg/kg body weight on days 1, 3 and 5 during first trimester and days 51, 53 and 55 during second trimester. Foetuses were harvested at day 78 of gestation all through Caesarean section. Foetal weights, crown-rump lengths (CRL), height at withers, heart girth, abdominal circumference, weights of adrenal glands and placental weight were evaluated. Specimens from placentas and adrenal glands were collected for histological analysis. Results showed that the mean placental weights, placental efficiency and foetal body weights were significantly (P

Key words: Dexamethasone;Foetuses;Placenta;Pregnancies;Sahel goats;Yankasa sheep



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