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IJCRR. 2017; 9(17): 37-40

A Review on Lorcaserin – A Selective 5-HT Serotonin Receptor Agonist in Obesity Management

Venkatesh P.; Venkhat Balaji B.R.; Venu Gopal K.; Vinodhini S.; Vinodhini T.; Vinodhini C.; Chitra K..

Lorcaserin is a novel anti-obesity agent. The study retrospect’s the pharmacokinetic effects, mode of action, adverse drug reactions and various uses of Lorcaserin. Lorcaserin is pro-opiomelanocortin neurons stimulator present in the nucleus of hypothalamus resulting in a peak melacortin-4 receptor activity, which results in satiety and decreased food intake. Though some side effects were reported, the potential benefits of Lorcaserin outweigh the risks. Serum drug monitoring is not required. Lorcaserin is a 5HT2C receptor agonist whose property may also be studied to treat anxiety, Alzheimer’s disease, depression and parkinsonism. Literature review was conducted to identify relevant studies. The study reviewed the pharmacokinetics, pharmacodynamics and clinical trials proposed so far on lorcaserin.

Key words: Lorcaserin;5-HT agonist;Anti-obesity

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