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J App Pharm Sci. 2017; 7(8): 123-130


Effect of Poikilacanthus glandulosus (Nees) Ariza branches and gallic acid against viability of Echinococcus ortleppi protoscoleces

Thiele Faccim de Brum; Roberta da Silva Jesus; Bianca Vargas Belke; Danieli Urach Monteiro; Natalia Jank Mossmann; Mariana Piana; Sílvio Terra Stefanello; Félix Alexandre Antunes Soares.

Abstract
The aim of this study was to assess the antioxidant capacity and to evaluate effect of P. glandulosus on the viability of protoscoleces of Echinococcus spp. as well as determine the possible substance in charge for this action. Echinococcus ortleppi protoscoleces were exposed front of the crude extract and butanol fraction and gallic acid at different times. Phytochemical study revealed the presence of triterpenoids, steroids, coumarins, catechins, phenols, anthocyanins, anthocyanidins and cardioactive heterosides. The highest polyphenol and flavonoids content was found in the ethyl acetate (151.34±1.71 mg/g) and dichlorometane (123.30±1.46 mg/g), respectively. For assays with DPPH the ethyl acetate fraction was highlighted (IC50 95.48±0.35 µg/mL) and the dichlorometane fraction significantly reduced lipid peroxidation (IC50 135.75±2.39 µg/mL) and also the oxidation of DCFH (15.6 µg/mL). The crude extract, butanol fraction and gallic acid showed scolicidal action of 100% at 15, 10 and 15 minutes, respectively.

Key words: Acanthaceae;antioxidant;gallic acid;protoscoleces;scolicidal agent



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