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J App Pharm Sci. 2017; 7(8): 137-141


Chemical Constituents of Artocarpus odoratissimus from Sarawak

Khong Heng Yen; Nyotia Nyokat; Clifford Junaidi Kutoi; Ahmad Sazali Hamzah; Isabel Fong Lim.

Abstract
Previous studies showed Artocarpus species are rich in phenolic compounds, including flavonoids, stilbenoids and arylbenzofurons. Furthermore, compounds from Artocarpus species exhibited diverse biological activities including antibacterial, antitubercular, antiviral, antifungal, antiplatelet, antiarthritic, tyrosinase inhibitory and cytotoxicity. However, there is no phytochemical investigation on the Artocarpus odoratissimus from Sarawak. Thus, it would be interesting to develop a chemical profile of such Sarawakian species. Various chromatographic methods, such as liquid vacuum chromatography, radial chromatography and column chromatograpy were employed to isolate the chemical constituents from the different parts, namely root, bark and leaves of Artocarpus odoratissimus. The isolation and purification using different solvents system ratio of hexane and ethyl acetate (10:0, 8:2, 6:4, 4:6, 2:8,0:10)and ethyl acetate and methanol (8:2) have led to two flavonoids; pinocembrin (1) and pinostrobin (2), and six triterpenoids; α-amyrin acetate (3), ß-amyrin acetate (4), traxateryl acetate (5), hexyl dodecanoate (6), ß-sitosterol (7) and stigmasterol (8). The structures (1) &– (8) were elucidated using various spectroscopic analysis, which included the Mass Spectroscopy (MS), Infrared (IR) spectroscopy, Ultra-violet (UV) spectroscopy and Nuclear Magnetic Resonance (NMR) spectroscopy, as well as by comparison with the reported data. Although the occurrence of compounds 1 and 2 were widely distributed in many of the plant species, but it was uncommon to the Artocarpus species which could be of chemotaxonomic significance to the genus Artocarpus.

Key words: Moraceae;Artocarpus odoratissimus;pinocembrin;pinostrobin;α-amyrin acetate;ß-amyrin acetate


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