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J App Pharm Sci. 2017; 7(8): 222-225


Protective Effects of Chives Leaves (Allium Schoenoprasum, L.) Infusion Against Ethylene Glycol and Ammonium Chloride Induced Nephrolithiasis in rats

Ginda Haro; Siti Morin Sinaga; I. Iksen; N. Nerdy; Suthinee Theerachetmongkol.

Abstract
ABSTRACT
The present day medical management of calculi is either costly or not without side effects. Hence, the search of anticalculi drugs from natural sources has been assumed greater importance. Chives (Allium schoenoprasum, L.) is a long-lived plant which is very easy to grow. It contained a variety of phytochemical compounds and various minerals. This aim of this research was to evaluate exposed of anticalculi activity of fresh and dried chives leaves infuse on male albino Wistar rats using 0.75 % ethylene glycol and 2 % ammonium chloride induction method. Animals in treatment group are given 10 % of fresh and dried chives leaves infuse. Anticalculi activity in the chives leaves infuse examined by observing the kidney weight ratio, calcium level in kidney, urinary calcium level, urinary oxalate level, and creatinine serum level. From the data obtained, there were significant differences in treated group from negative control group. The biggest effect of dissolving the calcium oxalate crystal in kidney was the dried chives leaves infuse. Based on the above results, it could be concluded that chives leaves could be an alternative to calculi disease treatment.

Key words: Anticalculi;Chives;Infuse;Ethylene Glycol;Calcium Oxalate;Atomic Absorption Spectrophotometry


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