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Hematological Changes And Tissue Biochemical Profile In Doxorubicin Induced Testicular Toxicity And Its Amelioration With Quercetin in Male Albino Wistar Rats

Chandrahas Sannat; D. Madhuri; M. Lakshman; A. Gopal Reddy.

Abstract
Study was conducted to evaluate hematological and tissue biochemical profile in doxorubicin induced testicular toxicity and its amelioration by quercetin. A total of 48 male albino rats (Wistar strain) were randomly divided into 4 groups consisting of 12 in each group. Group 1-Control, Group 2-Doxorubicin treated @4mg/kg b.wt intraperitoneally weekly once. Group 3-treated with quercetin @ 80mg/kg b.wt, orally daily. Group 4-treated with doxorubicin @ 4 mg/kg b.wt, intraperitoneally weekly once and quercetin @ 80mg/kg b.wt, orally daily. Hematological studies revealed that overall mean values of PCV, Hb, TEC, TLC were significantly (P

Key words: Rats;Doxorubicin;Quercetin;hematological changes;tissue oxidant profile


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