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Med Arh. 2017; 71(6): 424-429

Hemodynamic Responses to Tracheal Intubation in Elderly Patients: Intravenous or Spray of Lidocaine versus Fentanyl

Alireza Jalali; Ebrahim Nasiri; Mohsen Khoramian; Masood Saghafinia; Hasan Siamian.

Introduction: Laryngoscopy and tracheal intubation are known to increase sympathetic activity that may be detrimental to patients with preexisting ischaemic or hypertensive heart disease. Aim: The aim of this study was to compare of intravenous and oropharyngeal spray of lidocaine and high dose of fentanyl on systolic and diastolic blood pressures and heart rate of patients over 65 years during tracheal intubation. Material and Methods: In this clinical trial, 160 patients over 65 yrs who were randomly divided into five groups of 32 patients. For group one lidocaine spray 10%, group two intravenous lidocaine 1.5 mg/kg, group three lidocaine spray along with intravenous lidocaine 0.75 mg/kg, and for group four fentanyl 5µg/kg were administered and group five patients were controls which were given 1 mg of midazolam along with 2 µg/kg fentanyl. Systolic and diastolic blood pressures and heart rate were measured before and after anesthesia and intubation. ANOVA, Scheffe’s and Repeated measure tests were used for data comparison and P

Key words: Hemodynamics;intubation;Lidocaine;Fentanyl

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American Journal of Physiology, Biochemistry and Pharmacology


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