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Med Arh. 2017; 71(6): 385-390

Gender-related Histological Changes in the Thymus Gland After Pinealectomy and Short-term Melatonin Treatment in Rats

Irfan Susko; Selma Alicelebic; Esad Cosovic; Maida Sahinovic; Dina Kapic; Samra Custovic; Visnja Muzika.

Objectives: The aim of this study was to investigate the effects of pinealectomy and melatonin treatment on the rat thymus gland characteristics, taking into consideration possible gender differences. Materials and methods: Thirty adult Wistar rats of both sexes were divided into three groups. Group C and group PX served as control groups and included sham-pinealectomized and pinealectomized animals that were treated with 10% ethanol solution (0,1ml/daily, subcutaneous). Animals from third group (group PXM) underwent pinealectomy and seven days after surgery started receiving melatonin dissolved in 10% ethanol solution (3mg/kg/daily, subcutaneous). All animals were treated for 4 weeks. Results: Volume density of the thymus cortex showed statistically significant (p

Key words: rat;pineal gland;thymus gland;melatonin

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