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Histopathological and Scanning Electron Microscopy (SEM) of Paraquat (PQ) induced Acute Lung Injury (ALI) in experimental rats

Bathula Haripriya; Mekala Lakshman; Vallapureddy Sudha.

Abstract
The present study was aimed to know the histopathological and ultrastructural (SEM) alterations of lung due to PQ (Herbicide) in male Albino wistar rats. The experiment was carried out at different time intervals (24, 48, and 72 hrs). Histopathologically group 2 lung sections revealed increased thickness of septa and collapsed alveoli. Tertiary bronchiolar epithelial cells showed mild to moderate hyperplasia and focal areas inflammatory cells infiltration in peribronchiolar area. A dark inclusion like bodies and mild fibrous tissue proliferation in peribrochiolar along with severe congestion was also observed. Few bronchioles were shrunken. Scanning electron microscopy of group 2 lung slices showed irregular surface area with hemorrhages in bronchiolar area. Specimens of 48 and 72 hours showed thickened alveolar septa with mild to moderate fibrosis in peribranchiolar area.

Key words: Key words: Paraquat;Toxicity;ALI;Albino wistar rats;Histopatology and SEM


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