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J Islam Int Med Coll. 2018; 13(1): 09-36


Leptin Levels in Polycystic Ovarian Syndrome

Zarrin Khaliq Chaudari; Amer Siddiq; Amena Rahim; Muhammad Afzal; Abdul Khaliq Naveed; Shagufta Saeed Sial.

Abstract
BMI in young unmarried females with Polycystic Ovarian Syndrome.
Study Design: Descriptive Cross Sectional Study.
th th Place and Duration of Study: The study was conducted from 15 March 2016 to 15 March 2017 in Gynea and
Obs department of Benazir Bhutto Shaheed Hospital, Rawalpindi.
Materials and Methods: A sample of 77 young unmarried females of ages 15-30 years was recruited while
obtaining their written consent and divided into four groups using Rotterdam Criteria. These were control (non
PCOS) and study group (PCOS) with three subgroups based on their BMI (Lean, Overweight and Obese). Serum
Leptin assay was measured using Sandwich-ELISA method. A pre-designed questionnaire was used to collect
data from the patients. Data was analyzed in the Statistical Package of version 21.0, IBM SPSS.
Results: No association was found between leptin with FSH and LH in PCOS patients. However, body mass index
(BMI) and blood sugar fasting were significantly correlated with leptin in PCOS subjects and controls.
Correlation coefficient of leptin vs BSF is 0.488 with a p value of 0.000. Leptin was not significantly different
between PCOS and non-PCOS with normal BMI 3637.9 ± 1259.1 vs 3263.4 ± 1461.8 respectively with P value
0.331. In a subgroup analysis of lean, overweight and obese PCOS patients, each category showed different
mean serum leptin levels (3637.9 ± 1259.1 vs 4603.3 ± 1223.7 vs 4261.0 ± 1504.1 respectively) with p value
0.015.
Conclusion: Serum leptin has a positive association with BMI and blood glucose fasting in PCOS women.
However, it has no relationship with serum FSH and LH in PCOS women. The increase in BMI and BSF is the
reason of hyperleptinemia in PCOs

Key words: Blood Sugar Fasting;Body Mass Index;Polycystic Ovarian Syndrome;Serum Leptin



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