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Journal of Experimental and Integrative Medicine
Periodical of GESDAV
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ISSN: 1309-4572 (Print)
ISSN: 2146-3298 (Online)
Language: [ English ]  
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  » Volume 4, Issue 2
      pp. 75-149
  » Volume 4, Issue 1
      pp. 1-74

 

Open Access

Invited Review



Wound healing and the effect of pineal gland and melatonin

Jacek Drobnik.

Cited by (3)

Abstract
Wound healing is a complex phenomenon that is controlled by local and general regulatory mechanisms. The aim of the paper is to analyze recently-published data devoted to the regulation of wound repair by melatonin.
The effect of melatonin has been reported in different wound types healed with various mechanisms. The action of the pineal indoleamine is dependent on the used dose, time of application and target organ. Moreover, melatonin influences different phases of wound repair such as inflammation, by regulating the release of inflammatory mediators, cell proliferation and migration, by influencing angiogenesis, and the proliferation of fibroblasts, as well as the synthesis phase, by regulating collagen and glycosaminoglycan accumulation in the wounded milieu. Thus, healing of the skin wound, myocardial infarction, bone fractures and gastric ulcer is influenced by melatonin.
In patients with low levels of melatonin (elderly or β-blocker treated patients), its regulatory effects are expected to be impaired. Thus, the need for melatonin supplementation in those patients is postulated in the study.

Key words: Angiogenesis; Collagen; Fibroblasts; Glycosaminoglycans; Inflammation; Melatonin



REFERENCES
1. Menke NB, Ward K, Witten TM, Bonchev DG, Diegelmann RF. Impaired wound healing. Clin Dermatol 2007; 25:19-25.
[DOI via Crossref]    [Pubmed]   

2. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003; 83:835-70.
[
Pubmed]   

3. Roberts AB, Sporn MB, Assoian NK, Smith JM, Roche NS, Wakefield LM, Heine Ui, Liotta LA, Falanga V, Kehrl JH, Fauci AS. Transformig growth factor type betta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 1986; 83:4167-71.
[
DOI via Crossref]   

4. Grinnel F, Billingham RE, Burgess L. Distribution of fibronectin during wound healing in vivo. J Invest Dermatol 1981; 76:181-9.
[
DOI via Crossref]    [Pubmed]   

5. Blatti SP, Foster DN, Ranganathan G, Moses HL, Getz MJ. Induction of fibronectin gene transcription and mRNA is a primary response to growth factor stimulation of AKR-2B cells. Proc Natl Acad Sci USA 1988; 85:1119-23.
[
DOI via Crossref]   

6. Dąbrowski R, Drobnik J. The effect of disodium cromoglycate on the skin wound healing and collagen content in the wounds of rats. Acta Physiol Pol 1990; 41:195-8.
[
Pubmed]   

7. Dąbrowski R, Maslinski C. The effect of histamine on collagen formation and collagen polimerisation in the skin wound healing of guinea-pigs. Life Sci 1970; 9:189-202.
[
DOI via Crossref]   

8. Franz S, Ertl G, Bauersachs J. Mechanisms of the disease: Toll-like receptors in cardiovascular disease. Natl Clin Pract Cardiovasc Med 2007; 4:444-54.
[
DOI via Crossref]    [Pubmed]   

9. Oyama J, Blais C Jr, Liu X, Pu M, Kobzik L, Kelly RA, Bourcier T. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 2004; 109:784-9.
[
DOI via Crossref]    [Pubmed]   

10. Monaco JL, Lawrence WT. Acute wound healing an overview. Clin Plastic Surg 2003; 30:1-12.
[
DOI via Crossref]   

11. Rossen RD, Michael LH, Kagiyama A, Savage HE, Hanson G, Reisberg MA, Moake JN, Kim SH, Self D, Weakley S. Mechanism of complement activation after coronary artery occlusion: evidence that myocardial ischemia in dogs causes release of constituents of myocardial subcellular origin that complex with human C1q in vivo. Circ Res 1988; 62:572-84.
[
Pubmed]   

12. Niethammer P, Grabher C, Look AT, Mitchison TJ. A tissue scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature 2009; 459:996-9.
[
DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

13. Hensley K, Robinson KA, Gabbita SP, Salsman S, Floyd RA. Reactive oxygen species, cell signaling and cell injury. Free Radic Biol Med 2000; 28:1456-62.
[
DOI via Crossref]   

14. Sen CK. The general case for redox control in wound repair. Wound Rep Reg 2003; 11:431-8.
[
DOI via Crossref]    [Pubmed]   

15. Soneja A, Drews M, Malinski T. Role of nitric oxide, nitroxidative and oxidative stress in wound healing. Pharmacol Rep 2005; 57(suppl):108-19.
[
Pubmed]   

16. Jolly SR, Kane WJ, Bailie MB, Abrams GD, Lucchesi BR. Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase. Circ Res 1984; 54:277-85.
[
Pubmed]   

17. Petrov VV, Fagard RH, Lijenen PJ. Stimulation of collagen production by transforming growth factor-beta1 during differentiation of cardiac fibroblasts to myofibroblasts. Hypertension 2002; 39:258-63.
[
DOI via Crossref]    [Pubmed]   

18. Willems IE, Havenith MG, De Mey JG, Daemen MJ. The alpha-smooth muscle actin-positive cells in healing human myocardial scars. Am J Pathol 1994; 145:868-75.
[
Pubmed]    [PMC Free Fulltext]   

19. Eyden B. The myofibroblast: an assessment of controversial issues and definition useful in diagnosis and research. Ultrastr Pathol 2001; 25:39-50.
[
DOI via Crossref]    [Pubmed]   

20. Gerber HP, Condorelli F, Park J, Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes Flt-1 but not Flk-1/KDR is up-regulated by hypoxia. J Biol Chem 1999; 272:23659-67.
[
DOI via Crossref]    [Pubmed]   

21. Inoue K, Kusachi S, Niiya K, Kajikawa Y, Tsui T. Sequential changes in the distribution of type I and III collagens in the infarct zone immunochistochemical study of experimental myocardial infarction in the rat. Coron Artery Dis 1995; 6:153-8.
[
DOI via Crossref]    [Pubmed]   

22 Woessner IF. The determination of hydroxyproline in tissue and protein samples containing small proportions of this amino acid. Archs Biochem Biophys 1961; 93:440-5.
[
DOI via Crossref]   

23. Drobnik J, Krucinska I, Komisarczyk A, Szczepanowska A, Slotwinska D. Effects of nonwoven scaffolds of di-O-butyrylchitin and poly (ε-caprolactone) on wound healing. XXIInd Meeting of the Federation of the European Connective Tissue Societies, 3-7 July 2010, Davos, Switzerland, WO3-15.

24. Drobnik J, Szczepanowska A, Dabrowski R. Temporary increase of glycosaminoglycans in the heart after the left coronary artery ligation. Pathophysiology 2004; 11:35-9.
[
DOI via Crossref]    [Pubmed]   

25. Ishihara M, Fedarko NS, Conrad HE. Involvement of phosphatidylinositol and insulin in the coordinate regulation of proteoheparan sulphate metabolism and hepatocyte growth. J Biol Chem 1987; 262:4708-16.
[
Pubmed]   

26. Jackson RL, Busch SJ, Cardin AD. Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes. Physiol Rev 1991; 71:481-539.
[
Pubmed]   

27. Kucharz E, (ed). Biosynthesis of collagen. In: The collagens: Biochemistry and pathophysiology. Springer; Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong, Barcelona, Budapest; pp 31-53, 1992.

28. Gabbianni G, Ryan GB, Majno G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 1971; 27:549-50.
[
DOI via Crossref]    [Pubmed]   

29. Parks WC. Matrix metaloproteinases in repair. Wound Repair Regen 1999; 7:423-33.
[
DOI via Crossref]    [Pubmed]   

30. Takemura G, Ohno M, Hayakawa Y Misao J, Kanoh M, Ohno A, Uno Y, Minatoguchi S, Fujiwara T, Fujiwara H. Role of apoptosis in the disappearance of infiltrated and proliferated interstitial cells after myocardial infarction Circ Res 1998; 82:1130-8.
[
Pubmed]   

31. Hamalainen L, Oikarinen J, Kivirikko KI. Synthesis and degradation of type I procollagen mRNAs in cultured human skin fibroblasts and the effect of cortisol. J Biol Chem 1985; 260:720-5.
[
Pubmed]   

32. Gilliver SC, Ashworth JJ, Ashcroft GS. The hormonal regulation of cutaneous wound healing. Clin Dermatol 2007; 25:56-62.
[
DOI via Crossref]    [Pubmed]   

33. Sibbald GR, Woo KY. The biology of chronic foot ulcers in persons with diabetes. Diabetes Metab Res Rev 2008; 24:S25-30.
[
DOI via Crossref]    [Pubmed]   

34. Jogensen PH, Oxlud H. Growth hormone increases the biomechanical strength and collagen deposition rate during the early phase of skin wound healing. Wound Repair Regen 1996; 4:40-7.
[
DOI via Crossref]    [Pubmed]   

35. Kiaris H, Schally AV, Armatis P. Direct action of growth hormone-releasing hormone agonists JI-38 on normal human fibroblasts: evidence from studies on cell proliferation and c-myc proto-oncogene expression. Regul Pept 2001; 96:119-24.
[
DOI via Crossref]   

36. Safer JD, Crawford TM, Holick MF. Topical thyroid hormone accelerates wound healing in mice. Endocrinology 2005; 146:4425-30.
[
DOI via Crossref]    [Pubmed]   

37. Lijnen PJ, Petrov VV, Fagard RH. Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors. J Renin Angiotensin Aldosterone Syst 2001; 2:117-22.
[
Pubmed]   

38. Fraccarollo D, Galuppo P, Bauersachs J, Ertl G. Collagen accumulation after myocardial infarction: effects of ETA receptor blokade and implications for ealry remodeling. Circ Res 2002; 54:559-67.

39. Scott JR, Tamura RN, Muangman P Isik FF, Xie C, Gibran NS. Topical substance P increases inflammatory cell density in genetically diabetic murine wounds. Wound Repair Regen 2008; 16:529-33.
[
DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

40. Ekstrand AJ, Cao R, Bjorndahl M, Nystrom S, Jonsson-Rylander AC, Hassani H, Hallberg B, Nordlander M, Cao Y. Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockade of NPY-induced angiogenesis and delayed wound healing. Proc Natl Acad Sci USA 2003; 100:6033-8.
[
DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

41. Toda M, Suzuki T, Hosono K, Kurihara Y, Kurihara H, Hayashi I, Kitasato H, Hoka S, Majima M. Roles of calcitonin gene-related peptide in facilitation of wound healing and angiogenesis. Biomed Pharmacother 2008; 62:352-9.
[
DOI via Crossref]   

42. Muangman P, Muffley LA, Anthony JP, Spenny ML, Underwood RA, Olerud JE, Gibran NS. Nerve growth factor accelerates wound healing in diabetic mice. Wound Repair Regen 2004; 12:44-52.
[
DOI via Crossref]    [Pubmed]   

43. Rodero MP, Khosrotehrani K. Skin wound healing modulation by macrophages. Int J Clin Exp Pathol 210; 3:643-53.

44. Leibovich SJ, Ross R. The role of macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am J Pathol 1975; 78:71-100.
[
Pubmed]    [PMC Free Fulltext]   

45. Havran WL, Jameson JM. Epidermal T cells and wound healing. J Immunol 2010; 184:5423-8.
[
DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

46. Reiter RJ. Melatonin: the chemical expression of darkness. Mol Cell Endocrinol 1991; 79:C153-8.
[
DOI via Crossref]   

47. Klein DC. Arylalkylamine N-acetyltransferase “the Timezyme”. J Biol Chem 282:4233-7.
[
DOI via Crossref]    [Pubmed]   

48. Dubocovich ML, Delagrange P, Krause DN, Sugden D, Cardinali DP, Olcese J. International Union of basic and clinical pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors. Pharmacological Rev 2010; 62:343-80.
[
DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

49. Tetsuo M, Markey SP, Kopin IJ. Measurement of 6-hydroxymelatonin in human urine and its diurnal variations. Life Sci 1980; 27:105-9.
[
DOI via Crossref]   

50. Reppert SM, Weaver DR, Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron 1994; 13:1177-85.
[
DOI via Crossref]   

51. Reppert SM, Godson C, Mahle CD, Weaver DR, Slaugenhaupt SA, Gusella JF. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc Natl Acad Sci USA 1995; 92:8734-8.
[
DOI via Crossref]   

52. Winczyk K, Pawlikowski M, Lawnicka H, Kunert-Radek J, Spadoni G, Tarzia G, Karasek M. Effects of melatonin and melatonin receptors ligand N-[(4-methoxy-1H-indol-2-yl)metyl]propanamide on murine colon 38 cancer growth in vitro and in vivo. Neuro Endocrinol Let 2002; 23(Suppl1):50-4.

53. Leon J, Macias M, Escames G, Camacho E, Khaldy H, Martin M, Espinosa A, Gallo MA, Acuna-Castroviejo D. Structure related inhibition of calmodulin dependent neuronal nitric-oxide synthase activity by melatonin and synthetic kynurenines. Mol Pharmacol 2000; 58:967-75.
[
Pubmed]   

54. Rodriguez C, Mayo JC, Sainz RJ, Antolin I, Herrera F, Martin V, Reiter RJ. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004; 36:1-9.
[
DOI via Crossref]    [Pubmed]   

55. Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ. Melatonin: a potent endogenous hydroxyl radical scavenger. Endocrine Journal 1993; 1:57-60.

56. Hardeland R, Tan DX, Reiter RJ. Kynuramines, metabolites of melatonin and other indoles: resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009; 47:109-26.
[
DOI via Crossref]    [Pubmed]   

57. Chen Z, Chau CC, Gao J, Chua KW, Ho YS, Hamdy RC, Chua BH. Prevention of ischemia/reperfusion induced cardiac apoptosis and injury by melaton is independent of glutathione peroxidase 1. J Pineal Res 2009; 46:235-41.
[
DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

58. Karbownik M, Reiter RJ. Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation. Proc Soc Exp Biol Med 2000; 225:9-22.
[
DOI via Crossref]    [Pubmed]   

59. Cunnane SC, Manku MS, Horrobin DF. The pineal and regulation of fibrosis: Pinealectomy as a model of primary biliary cirrhosis: Roles of melatonin and prostaglandins in fibrosis and regulation of T lymphocytes. Med Hypotheses 1979; 5:403-14.
[
DOI via Crossref]   

60. Elkind AH, Friedman AP, Bachman A, Siegelman SS, Sacs OW. Silent retroperitonela fibrosis with methysergide therapy. JAMA 1968; 206:1041-4.
[
DOI via Crossref]   

61. Graham JR. Cardiac and pulmonary fibrosis during methysergide therapy for headache. Am J Med Sci 1967; 254:1-12.
[
DOI via Crossref]    [Pubmed]   

62. Riquet FB, Lai WF, Birkhead JR, Suen LF, Karsenty G, Goldring MB. Suppresion of type I collagen gene expression by prostaglandins in fibroblasts is mediated at the transcriptional level. Mol Med 2000; 6:705-19.
[
Pubmed]    [PMC Free Fulltext]   

63. Drobnik J, Janus J, Dabrowski R, Szczepanowska A. The healing process, collagen and chondroitin-4-sulphate accumulation in the wound are conrolled by the pineal gland. Polish J Endocrinol 1995; 46:411-8.

64. Drobnik J, Dabrowski R, Szczepanowska A. Collagen accumulation in the wound of a rat is controlled by the pineal gland. Biomed Let 1995; 51:23-9.

65. Drobnik J, Dabrowski R. Melatonin supresses the pinealectomy-induced elevation of collagen content in the wound. Cytobios 1996; 85:51-8.
[
Pubmed]   

66. Drobnik J, Dabrowski R. The opposite effect of morning or afternoon application of melatonin on collagen accumulation in the sponge-induced granuloma. Neuro Endocrinol Lett 2000; 1:195-8.

67. Bulbuller N, Dogru O, Yekeler H, Cetinkaya Z, Ilhan N, Kirkil C. Effect of melatonin on wound healing in normal and pinealectomized rats. J Surg Res 2005; 123:3-7.
[
DOI via Crossref]    [Pubmed]   

68. Ozler M, Korkmaz A, Uysal B, Simsek K, Ozkan C, Topal T, Oter S. Effects of topical melatonin and vitamin E in rat ischemic wound model. J Exp Integr Med 2011; 1:123-9.
[
DOI via Crossref]   

69. Basak PY, Agalar F, Gultekin F, Eroglu E, Altuntas I, Agalar C. The effect of termal injury and melatonin on incisional wound healing. Turkish Journal of Trauma & Emergency Surgery 2003; 9:96-101.
[
Pubmed]   

70. Tahan V, Ozaras R, Canbakan B, Uzun H, Aydin S, Yildirim B, Aytekin H, Ozbay G, Mert A, Senturk H. Melatonin reduces dimethylnitrosamine-induced liver fibrosis in rats. J Pineal Res 2004; 37:78-84.
[
DOI via Crossref]    [Pubmed]   

71. Ustuntag B, Cinkilinc N, Halifeoglu I, Canatan H, Ozercan I.H. Effect of melatonin on hepatic fibrogenesis, vitamin C hydroxyproline levels in liver of ethanol-fed rats. Turk J Med Sci 2000; 30:333-40.

72. Pugazhenthi K, Kapoor M, Clarkson AN, Hall I, Appleton I. Melatonin accelerates the process of wound repair in full-thickness incisional wounds. J Pineal Res 2008; 44:387-96.
[
DOI via Crossref]    [Pubmed]   

73. Drobnik J, Dabrowski R. Pinealectomy-induced elevation of collagen content in intact skin is supressed by melatonin application. Cytobios 1999; 100:49-55.
[
Pubmed]   

74. Carossino AM, Lombardi A, Matucci-Cerinic M, Pignone A, Cagnoni M. Effect of melatonin on normal and sclerodermic skin fibroblasts proliferation. Clin Exp Rheumatol 1996; 14:493-8.
[
Pubmed]   

75. Choi SL, Dadakhujaev S, Ryu H, Im Kim T, Kim EK. Melatonin protects against oxidative stress in granular corneal dystrophy type 2 corneal fibroblasts by mechanisms that involve membrane melatonin receptors. J Pineal Res 2011; 51:94-103.
[
DOI via Crossref]    [Pubmed]   

76. Maldonado MD, Siu AW, Sanchez-Hidalgo M, Acuna-Castroviejo D, Escames G. Melatonin and lipid uptake by murine fibroblasts: clinical implications. Neuro Endocrinol Lett 2006; 27:601-8.
[
Pubmed]   

77. Ishii H, Tanaka N, Kobayashi M, Kato M, Sakuma Y. Gene structures biochemical characterization and distribution of rat melatonin receptors. J Physiol Sci 2008; 59:37-47.
[
DOI via Crossref]    [Pubmed]   

78. Finocchiaro LM, Glikin GC. Intracellular melatonin distribution in cultured cell lines. J Pineal Res 1998; 24:22-34.
[
DOI via Crossref]    [Pubmed]   

79. Drobnik J, Karbownik-Lewinska M, Szczepanowska A, Slotwihska D, Olczak S, Jakubowski L, Dabrowski R. Regulatory influence of melatonin on collagen accumulation in the infarcted heart scar. J Pineal Res 2008; 45:285-90.
[
DOI via Crossref]    [Pubmed]   

80. Brismar K, Hylander B, Eliasson K, Rossner S, Wetterberg L. Melatonin secretion related to side-effects of beta-blockers from the central nervous system. Acta Med Scand 1988; 223:525-30.
[
DOI via Crossref]   

81. Reiter RJ, King TS, Richardson BA, Hurlbut EC. Studies on pineal melatonin levels in diurnal species the eastern chipmunk (Tamias striatus): effects of light at night, propranolol administration or superior cervical ganglionectomy. J Neural Transm 1982; 54:275-84.
[
DOI via Crossref]    [Pubmed]   

82. Drobnik J, Olczak S, Owczarek K, Hrabec Z, Hrabec E. Melatonin augments expression of the procollagen α1(I) and α1(III) genes, in the infarcted heart scar of pinealectomised rats. Connective Tissue Res 2010; 51:491-6.
[
DOI via Crossref]    [Pubmed]   

83. Drobnik J, Slotwinska D, Olczak S, Tosik D, Pieniazek A, Matczak K, Koceva-Chyla A, Szczepanowska A. Pharmacological doses of melatonin reduce the glycosaminoglycan level within the infarcted heart scar. J Physiol Pharmacol 2011; 62:29-35.
[
Pubmed]   

84. Ostrowska Z, Kos-Kudla B, Swietochowska E, Marek B, Kajdaniuk D, Gorski J. Assessment of the relationship between dynamic pattern of nighttime levels of melatonin and chosen biochemical markers of bone metabolism in a rat model of postmenopausal osteoporosis. Neuro Endocrinol Lett 2001; 22:129-36.
[
Pubmed]   

85. Halici M, Oner M, Guney A, Canoz O, Narin F, Halici C. Melatonin promotes fracture healing in the rat model. Joint Diseases & Related Surgery 2010; 21:172-7.

86. Nakade O, Koyama H, Ariji H, Yajima A, Kaku T. Melatonin stimulates proliferation and type I collagen synthesis in human bone cells in vitro. J Pineal Res 1999; 27:106-10.
[
DOI via Crossref]    [Pubmed]   

87. Ganguly K, Sharma AV, Reiter RJ, Swarnakar S. Melatonin promotes angiogenesis during protection and healing of indometacin-induced gastric ulcer: role matrix metalloproteinase-2. J Pineal Res 2010; 49:130-40.
[
Pubmed]   

88. Konturek PC, Konturek SJ, Burnat G, Brzozowski T, Reiter RJ. Dynamic physiological and molecular changes in gastric ulcer healing ahieved by melatonin and its precursor L-tryptophan in rats. J Pineal Res 2008; 45:180-90.
[
DOI via Crossref]    [Pubmed]   

89. Ganguly K, Swarnakar S. Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. J Pineal Res 2009; 47:43-55.
[
DOI via Crossref]    [Pubmed]   

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Drobnik J. Wound healing and the effect of pineal gland and melatonin. J Exp Integr Med. 2012; 2(1): 3-14. doi:10.5455/jeim.040112.ir.009



Web Style

Drobnik J. Wound healing and the effect of pineal gland and melatonin. www.scopemed.org/?mno=12299 [Access: August 30, 2014]. doi:10.5455/jeim.040112.ir.009



AMA (American Medical Association) Style

Drobnik J. Wound healing and the effect of pineal gland and melatonin. J Exp Integr Med. 2012; 2(1): 3-14. doi:10.5455/jeim.040112.ir.009



Vancouver/ICMJE Style

Drobnik J. Wound healing and the effect of pineal gland and melatonin. J Exp Integr Med. (2012), [cited August 30, 2014]; 2(1): 3-14. doi:10.5455/jeim.040112.ir.009



Harvard Style

Drobnik, J. (2012) Wound healing and the effect of pineal gland and melatonin. J Exp Integr Med, 2 (1), 3-14. doi:10.5455/jeim.040112.ir.009



Turabian Style

Drobnik, Jacek. 2012. Wound healing and the effect of pineal gland and melatonin. Journal of Experimental and Integrative Medicine, 2 (1), 3-14. doi:10.5455/jeim.040112.ir.009



Chicago Style

Drobnik, Jacek. "Wound healing and the effect of pineal gland and melatonin." Journal of Experimental and Integrative Medicine 2 (2012), 3-14. doi:10.5455/jeim.040112.ir.009



MLA (The Modern Language Association) Style

Drobnik, Jacek. "Wound healing and the effect of pineal gland and melatonin." Journal of Experimental and Integrative Medicine 2.1 (2012), 3-14. Print. doi:10.5455/jeim.040112.ir.009



APA (American Psychological Association) Style

Drobnik, J. (2012) Wound healing and the effect of pineal gland and melatonin. Journal of Experimental and Integrative Medicine, 2 (1), 3-14. doi:10.5455/jeim.040112.ir.009



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