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| TAF Preventive Medicine Bulletin. 2010; 9(4): 297-302 Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents Emmanuel Olorunju Awe, Modupe Janet Makinde, Kamoru Olayemi Wakeel1, Simeon Olatunde Kolawole.Abstract
AIM: The continued search for potential and safe anti-inflammatory agents is important, in view of the roles played by proinflammatory factors in diseases such as asthma, rheumatoid arthritis, cancer and neurodegerative disorders. The Nigerian flora is rich in medicinal plants which are employed in traditional folk medicine for various inflammatory disorders. We therefore evaluate the antiinflammatory activity of the aqueous extract of the leaves of.
METHOD: The antiinflammatory activity was evaluated using egg albumin, agar-induced paw edema models for acute inflammation, complete Freud Adjuvant (CFA)-induced arthritis and cotton pellets granuloma models for chronic inflammation in rats.
RESULTS: PSE, produced significant (P<0.05-0.01) and dose-dependent (100-400 mg/kg) reduction of paw edema volume in rats. In chronic inflammation (CFA-induced arthritis), the extract significantly (P< 0.05) inhibited edematous response in a dose-related manner, provoking an inhibitory effect (61%, maximum inhibition) at 400 mg/kg on day 21 same as non-steroidal anti-inflammatory drug, indomethacin (5 mg/kg). PSE, also significantly (P<0.05) and dose-dependently reduce the granuloma weight in chronic model of granuloma pouch in rats.
CONCLUSION: The findings of the present study indicate that PSE possesses anti-inflammatory activity and thus lend pharmacological credence to the suggested use of the plant as a natural remedy in the treatment, management and/or control of inflammatory conditions in some rural communities of Nigeria.
Key words: Pyrenacanthia Staudtii, Aqueous Extract, Anti-İnflammatory Activity
Kemirgenlerde Pyrenacanthia Staudtii Engl. (Icacinaceae) Bitkisinin Sıvı Yaprak Ekstresinin Antiinflamatuar Etkisi Özet
GİRİŞ: Astım, romatoid artrit, kanser ve nörodejeneratif bozukluklar gibi hastalıklarda, proinflamatuar faktörlerin rolleri açısından, potansiyel ve güvenli anti-inflamatuar ajanlar için yapılan sürekli aramalar önemlidir. Nijerya’nın florası tıbbi bitkiler bakımından zengin olup, bu bitkiler geleneksel halk tıbbında çeşitli enflamatuar hastalıklar için kullanılmaktadır. Bu kapsamda Pyrenacanthia staudtii Engl. (Icacinaceae) (PSE) yapraklarının sulu ekstresinin antienflamatuar aktivitesi incelenmiştir.
METOD: Antiinflamatuvar aktivite; yumurta albumin, agar-akut inflamasyon için modeli, komple Freud Adjuvanı (CFA)-indüklenmiş artrit ve sıçanlarda kronik inflamasyon için pamuk pellet granülom modelleri kullanılarak değerlendirilmiştir.
BULGULAR: PSE, pençe ödemi miktarını doz bağımlı olarak azaltmıştır (100-400 mg/kg) ve bu azalış istatistiksel olarak anlamlıdır (P<0.05-0.01). Kronik inflamasyonda (CFA-indüklenmiş artrit) ekstre; ödematöz cevabı doz bağımlı olarak anlamlı şekilde inhibe etmiş (p<0.05), bu inhibisyonun (61%, maksimum inhibisyon); 400 mg/kg dozda ve 21 günlük kullanımda, non-sterodi anti-inflamatuar indometazinin (5 mg/kg) yaptığına eşit olduğu saptanmıştır. Aynı zamanda PSE, ratlarda kronik granülom kese modelinde granülom ağırlığını doza bağımlı ve anlamlı olarak azaltmıştır (p <0.05).
SONUÇ: Bu çalışmanın bulguları, anti-enflamatuar aktiviteye sahip ve farmakolojik olarak güvenli olduğu gösterilen PSE’nin, Nijerya'nın bazı kırsal topluluklarda iltihabi hastalık tedavisi, kontrolü ve/veya yönetiminde doğal bir ilaç olarak önerilebileceğini göstermiştir.
Anahtar Kelimeler: Pyrenacanthia Staudtii, Sulu Ekstrakt, Anti-İnflamatuar Etkinlik
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Viewed: 22 Downloaded: 24 Emailed: 0 | Howto Cite this Article | | Pubmed Style Awe EO, Makinde MJ, Wakeel1 KO, Kolawole SO. Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents. TAF Prev Med Bull. 2010; 9(4): 297-302.
Web StyleAwe EO, Makinde MJ, Wakeel1 KO, Kolawole SO. Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents. www.scopemed.org/?mno=1338 [Access: September 03, 2010]
AMA (American Medical Assoc.) StyleAwe EO, Makinde MJ, Wakeel1 KO, Kolawole SO. Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents. TAF Prev Med Bull. 2010; 9(4): 297-302.
Vancouver/ICMJE StyleAwe EO, Makinde MJ, Wakeel1 KO, Kolawole SO. Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents. TAF Prev Med Bull. (2010), [cited September 03, 2010]; 9(4): 297-302.
Harvard StyleAwe, E. O., Makinde, M. J., Wakeel1, K. O. & Kolawole, S. O. (2010) Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents. TAF Prev Med Bull, 9 (4), 297-302.
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