Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Research

RMJ. 2012; 37(3): 258-263

Frequency and severity of erectile dysfunction in Child Turcot Pugh classes of liver cirrhosis

Shaikh Khalid Muhammad, Bashir Ahmed Shaikh, Azizullah Jalbani, Kouro Mal Gurbakshani.

OBJECTIVES: To determine the frequency and severity of erectile dysfunction (ED) in Child Turcot Pugh (CTP) classes of liver cirrhosis using international index for erectile function -5 (IIEF - 5).

METHODOLOGY: This 1 year study was started in January 2010. 589 cirrhotic patients meeting our selection criteria were enrolled from Hepatology clinic of C.M.C, Larkana and asked 5 questions of IIEF-5 to assess the frequency and severity of ED. Clinical examination was performed to detect ascites and hepatic encephalopathy. Blood samples were drawn for serum bilirubin, albumin and INR.
Data was transferred and analyzed using SPSS-19. Categorical response variables such as age, severity of ED, CTP class, bilirubin, albumin, INR, ascites and hepatic encephalopathy were compared in erectile dysfunction positive and negative cases by Chi-square test. P value of less than 0.05 was taken statistically significant.

RESULTS: ED was reported by 476 (80.8%) participants. 219 (37.2%) reported severe ED, 133 (22.6%) moderate ED, 58 (9.8%) mild to moderate ED and 66 (11.2%) mild ED. Patients with ED were more likely to be in CTP class C (p < 0.000) with odd risk of 8.49 (95% CI: 4.73 – 16.53). Patients with ED had elevated INR (p < 0.000), serum bilirubin (p < 0.000) and decreased serum albumin (p < 0.000) with odds of 8.49 (95% CI: 3.86 – 18.65), 3.79 (2.02 – 7.12) and 3.25 (95% CI: 1.94 – 5.45) respectively. ED reporting patients tend to have severe or resistant ascites and higher grades of encephalopathy with odds of 3.00 (95% CI: 1.94 – 4.64) and 4.14(95% CI: 2.15 – 7.95).

CONCLUSION: ED was reported in 80.8% cirrhotic patients, and most of them in CTP class C. Patients reporting ED had elevated INR, serum bilirubin, suppressed serum albumin, severe or resistant ascites and higher grades of hepatic encephalopathy.

Key words: Erectile Dysfunction (ED), Child Turcot Pugh (CTP), International Index for Erectile Function - 5 (IIEF-5), cirrhosis of liver.

Share this Article

American Journal of Research in Medical Sciences


ScopeMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons