Home    eJManager.com Add Your Journal   |    Follow on Twitter   |    Subscribe to List

Directory for Medical Articles
 

Open Access

Original Research

J. Phys. Pharm. Adv.. 2014; 4(2): 337-341


Effect of Gongronema Latifolium Leaves Ethanolic Extract on Paracetamol-Induced Hepatotoxicity in Rats

Enyinnaya Ogbonnaya, Sylvester Uanseoje, Samuel Ojeaburu..

Abstract
Gongronema latifolium is a perennial edible plant used locally, especially in the South-Eastern Nigeria as spice in foods or eaten raw for its medicinal benefit. It has been noted for its anti-diabetic, anti-hypertensive and anti-oxidative properties among others. This study investigates the effect of the Gongronema latifolium leaf ethanolic (GLE) extract on paracetamol-induced hepatotoxicity in rats. Twenty four wister albino rats were randomly placed into six (6) groups of four (4) animals per group. Two groups serve as control and received either olive oil (oral) or paracetamol (200mg/ kg bw, ip) alone. Three experimental groups received paracetamol(200mg/kg bw,ip) before, after or simultaneously with administration of GLE (1g/kg bw, oral). The remaining group received extract (1g/kg bw, oral) alone. Animals were sacrificed after 6 days of treatment and serum observed for liver function parameters. The results show significant (P

Key words: Gongronema latifolium, hepatotoxicity,paracetamol, hepatoprotective.



Share this Article




ScopeMed Home
Follow ScopeMed on Twitter
Article Tools
Job Opportunities/Service Offers
eJManager OJMS
eJPort Journal Hosting
About ScopeMed
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Service of eJManager LLC Publishing for Scientific Publications. Copyright © ScopeMedź Information Services.
Scopemed Buttons