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J. Phys. Pharm. Adv.. 2014; 4(2): 337-341

Effect of Gongronema Latifolium Leaves Ethanolic Extract on Paracetamol-Induced Hepatotoxicity in Rats

Enyinnaya Ogbonnaya, Sylvester Uanseoje, Samuel Ojeaburu..

Gongronema latifolium is a perennial edible plant used locally, especially in the South-Eastern Nigeria as spice in foods or eaten raw for its medicinal benefit. It has been noted for its anti-diabetic, anti-hypertensive and anti-oxidative properties among others. This study investigates the effect of the Gongronema latifolium leaf ethanolic (GLE) extract on paracetamol-induced hepatotoxicity in rats. Twenty four wister albino rats were randomly placed into six (6) groups of four (4) animals per group. Two groups serve as control and received either olive oil (oral) or paracetamol (200mg/ kg bw, ip) alone. Three experimental groups received paracetamol(200mg/kg bw,ip) before, after or simultaneously with administration of GLE (1g/kg bw, oral). The remaining group received extract (1g/kg bw, oral) alone. Animals were sacrificed after 6 days of treatment and serum observed for liver function parameters. The results show significant (P

Key words: Gongronema latifolium, hepatotoxicity,paracetamol, hepatoprotective.

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American Journal of Preventive Medicine and Public Health


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