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Case Report

J Pak Med Assoc. 2014; 64(6): 711-713

Calciphylaxis leading to penile necrosis

Imran Haider,Muhammad Siddiqui,Wisam Naji,Maria Sheikh, Ayesha Waqar.

Penile gangrene is a rare disease. It represents a poor
prognostic sign in end stage renal disease (ESRD) patients
and an indicator of metastatic vascular calcification.
Pathogenesis of this life threatening condition is not
clearly understood and treatment is also controversial.
We describe the case of a 61-year-old man known to have
diabetes mellitus, chronic renal failure on haemodialysis,
who was complaining of worsening groin pain for 4
weeks. On examination dry gangrene of glans penis was
noted. Cultures from the penis showed multiple
organisms. Computed tomography (CT) showed diffuse
calcification of external and internal iliac arteries. Later, he
developed caciphylaxis of right anterior thigh .His overall
condition did not improve in spite of adequate antibiotics
and he was shifted to intensive care unit (ICU) where he
required high doses of vasopressors. Clinically he kept
deteriorating and passed away due to septic shock.

Key words: Calciphylaxis, Penile, Renal disease, Necrosis.

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