Journal Management System
 
Home  |   Add your Journal  |   Features  |   Journal List
Author Login | Reviewer Login | Editor Login
Search  

Medical Archives
Periodical of AVICENA, d.o.o., Sarajevo
Journal Home Page
ISSN: 0350-199X (Print)
ISSN: 1986-5961 (Online)
Language: [ English ]  
News / Announcements

  » Volume 68, Issue 6
      pp. 372-4135
  » Volume 68, Issue 5
      pp. 300-363
  » Volume 68, Issue 4
      pp. 228-293
  » Volume 68, Issue 3
      pp. 156-222
  » Volume 68, Issue 2
      pp. 76-146
  » Volume 68, Issue 1
      pp. 4-70

 

Open Access

Original Research



The Effects of Folic Acid on Markers of Endothelial Function in Patients with Type 1 Diabetes Mellitus

Zahra Alian, Mahin Hashemipour, Elham Hashemi Dehkordi, Silva Hovsepian, Massoud Amini, Mohammad Hassan Moadab, Shaghayegh Haghjooy Javanmard.

Cited by (2)

Abstract
Background: Endothelial dysfunction is considered as a fundamental and also preventable factor in the progression of vascular complications among type 1 diabetic patient. It occurs before the clinical manifestation of the mentioned complications. The aim of this study was to evaluate the effects of folic acid on endothelial function by measurements of adhesion molecules and von Willebrand factor (vWF) in patients with type 1 diabetes in Isfahan, Iran. Methods: This double blind, placebo-controlled crossover trial included type 1 diabetic patients aged 5-20 years old. Selected patients were randomized into two groups of A and B to receive folic acid 5 mg daily or placebo for 8 weeks. After a 2-week washout period, patients in the two groups were swapped to receive placebo or folic acid, respectively, for another 8 weeks. Blood and urine samples were taken to evaluate glycosylated hemoglobin (HbA1c), folic acid, vWF, intracellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), and microalbuminuria levels. Results of these measurements were compared in the two groups before and after folic acid and placebo administrations. Results: Fifty five type 1 diabetic patients aged 12.1 ± 3.4 years with diabetes duration of 3.9 ± 2.1 years were enrolled. Mean of folic acid level in the two studied groups was increased significantly (10.1 ± 3.8 vs. 21.2 ± 1.1in group A and 15.5 ± 1.9 vs. 19.9 ± 2.8 in group B, p < 0.05). Mean of VCAM and microalbuminuria was decreased significantly after folic acid administration in the two groups (p < 0.05). Mean of HbA1c, ICAM and vWF did not significantly change after folic acid administration in the two groups (p > 0.05). Conclusion: Folic acid administration decreased the level of endothelial dysfunction measured by adhesion molecules, especially VCAM and microalbuminuria. However, it did not significantly affect vWF. Further studies with larger sample size and long-term administration of folic acid are necessary for making precise decisions in this field.

Key words: endothelial function, Diabetes Mellitus, folic acid.



REFERENCES
1. Klingensmith G, Kaufman F, Schatz D, Clarke W. Care of children with diabetes in the school and day care setting. Diabetes Care. 2003; 26(Suppl 1): S131-S135.
[DOI via Crossref]   

2. Schiekofer S, Balletshofer B, Andrassy M, Bierhaus A, Nawroth PP. Endothelial dysfunction in diabetes mellitus. Semin Thromb Hemost. 2000; 26(5): 503-511.
[
DOI via Crossref]    [Pubmed]   

3. Jin SM, Noh CI, Yang SW, Bae EJ, Shin CH, Chung HR, et al. Endothelial dysfunction and microvascular complications in type 1 diabetes mellitus. J Korean Med Sci. 2008; 23(1): 77-82.
[
DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

4. Quyyumi AA. Endothelial function in health and disease: new insights into the genesis of cardiovascular disease. Am J Med. 1998; 105(1A): 32S-39S.
[
DOI via Crossref]   

5. Behrendt D, Ganz P. Endothelial function. From vascular biology to clinical applications. Am J Cardiol. 2002; 90(10C): 40L-48L
[
DOI via Crossref]   

6. Hadi HA, Suwaidi JA. Endothelial dysfunction in diabetes mellitus. Vasc Health Risk Manag. 2007; 3(6): 853-876.
[
Pubmed]    [PMC Free Fulltext]   

7. Ceriello A, Esposito K, Ihnat M, Thorpe J, Giugliano D. Long-term glycemic control influences the long-lasting effect of hyperglycemia on endothelial function in type 1 Diabetes. J Clin Endocrinol Metab. 2009; 94(8): 2751-6.
[
DOI via Crossref]   

8. Praticò D. Antioxidants and endothelium protection. Atherosclerosis. 2005; 181(2): 215-224.
[
DOI via Crossref]    [Pubmed]   

9. Tiefenbacher CP, Friedrich S, Bleeke T, Vahl C, Chen X, Niroomand F. ACE inhibitors and statins acutely improve endothelial dysfunction of human coronary arterioles. Am J Physiol Heart Circ Physiol. 2004; 286(4): H1425-32.
[
DOI via Crossref]    [Pubmed]   

10. Wiltshire EJ, Gent R, Hirte C, Pena A, Thomas DW, Couper JJ. Endothelial dysfunction relates to folic acid status in children and adolescents with type I diabetes. Diabetes. 2002; 51(7): 2282-2286.
[
DOI via Crossref]    [Pubmed]   

11. Peña AS, Wiltshire E, Gent R, Hirte C, Couper J. Folic acid improves endothelial function in children and adolescents with type 1 diabetes. J Pediatr. 2004; 144(4): 500-504.
[
DOI via Crossref]    [Pubmed]   

12. Al-Qaisi M, Kharbanda RK, Mittal TK, Donald AE. Measurement of endothelial function and its clinical utility for cardiovascular risk. Vasc Health Risk Manag. 2008; 4(3): 647-652.
[
Pubmed]    [PMC Free Fulltext]   

13. Calles-Escandon J, Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev. 2001; 22(1): 36-52.
[
DOI via Crossref]    [Pubmed]   

14. Blann AD. Plasma von Willebrand factor, thrombosis, and the endothelium: the first 30 years. Thromb Haemost. 2006; 95(1): 49-55.
[
Pubmed]   

15. Videm V, Albrigtsen M. Soluble ICAM-1 and VCAM-1 as markers of endothelial activation. Scand J Immunol. 2008; 67(5): 523-531.
[
DOI via Crossref]    [Pubmed]   

16. Goldberg RB. Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications. J Clin Endocrinol Metab. 2009; 94(9): 3171-3182.
[
DOI via Crossref]   

17. Halimi JM, Hadjadj S, Aboyans V, Allaert FA, Artigou JY, Beaufils M, et al. Microalbuminuria and urinary albumin excretion: French guidelines. Ann Biol Clin (Paris). 2008; 66(3): 277-84. [Article in French].


18. Behrendt D, Ganz P. Endothelial function. From vascular biology to clinical applications. Am J Cardiol. 2002; 90(10C): 40L-48L.
[
DOI via Crossref]   

19. Targher G, Bertolini L, Zoppini G, Zenari L, Falezza G. Increased plasma markers of inflammation and endothelial dysfunction and their association with microvascular complications in Type 1 diabetic patients without clinically manifest macroangiopathy. Diabet Med. 2005; 22(8): 999-1004.
[
DOI via Crossref]    [Pubmed]   

20. Velarde MS, Del R Carrizo T, Prado MM, Díaz EI, Fonio MC, Bazán MC, et al. Inflammation markers and endothelial disfunction in children with type 1 diabetes. Medicina (B Aires). 2010; 70(1): 44-48. [Article in Spanish].


21. MacKenzie KE, Wiltshire EJ, Gent R, Hirte C, Piotto L, Couper JJ. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus. Pediatrics. 2006; 118(1): 242-253.
[
DOI via Crossref]    [Pubmed]   

22. Peña AS, Wiltshire E, Gent R, Piotto L, Hirte C, Couper J. Folic acid does not improve endothelial function in obese children and adolescents. Diabetes Care. 2007; 30(8): 2122-2127.
[
DOI via Crossref]    [Pubmed]   

23. Wotherspoon F, Laight DW, Turner C, Meeking DR, Allard SE, Munday LJ, et al. The effect of oral folic acid upon plasma homocysteine, endothelial function and oxidative stress in patients with type 1 diabetes and microalbuminuria. Int J Clin Pract. 2008; 62(4): 569-574.
[
DOI via Crossref]    [Pubmed]   

24. Głowińska B, Urban M, Peczyńska J, Szczepańska-Kostro J. Selected adhesion molecules: sICAM-1 and sVCAM-1 as markers of endothelial dysfunction in diabetic children and adolescence. Pol Merkur Lekarski. 2003; 14(81): 205-209.


25. Shahab A. Why does diabetes mellitus increase the risk of cardiovascular disease? Acta Med Indones. 2006; 38(1): 33-41.
[
Pubmed]   

26. Williams MD, Nadler JL. Inflammatory mechanisms of diabetic complications. Curr Diab Rep. 2007; 7(3): 242-248.
[
DOI via Crossref]    [Pubmed]   

27. Fasching P, Veitl M, Rohac M, Streli C, Schneider B, Waldhäusl W, et al. Elevated concentrations of circulating adhesion molecules and their association with microvascular complications in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1996; 81(12): 4313-4317.
[
DOI via Crossref]   

28. Verrotti A, Greco R, Basciani F, Morgese G, Chiarelli F. von Willebrand factor and its propeptide in children with diabetes. Relation between endothelial dysfunction and microalbuminuria. Pediatr Res. 2003; 53(3): 382-386.
[
DOI via Crossref]    [Pubmed]   

29. Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creager MA. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation. 1993; 88(6): 2510-2516.
[
Pubmed]   

30. Ichinose K, Kawasaki E, Eguchi K. Recent advancement of understanding pathogenesis of type 1 diabetes and potential relevance to diabetic nephropathy. Am J Am J Nephrol. 2007; 27(6): 554-564.
[
DOI via Crossref]    [Pubmed]   

31. Satchell SC, Tooke JE. What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium? Diabetologia. 2008; 51(5): 714-725.
[
DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

32. Sahakyan K, Klein BE, Lee KE, Tsai MY, Klein R. Inflammatory and endothelial dysfunction markers and proteinuria in persons with type 1 diabetes mellitus. Eur J Endocrinol 2010; 162(6): 1101-1105.
[
DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

33. Doshi SN, McDowell IF, Moat SJ, Payne N, Durrant HJ, Lewis MJ, et al. Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation. 2002; 105(1): 22-26.
[
DOI via Crossref]    [Pubmed]   

34. Thambyrajah J, Landray MJ, McGlynn FJ, Jones HJ, Wheeler DC, Townend JN. A randomized double blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function inpatients with coronary artery disease. J Am Coll Cardiol. 2001; 37(7): 1858-1863.
[
DOI via Crossref]   

This Article Cited By the following articles

The effect of homocysteine-lowering therapy with folic acid on flow-mediated vasodilation in patients with coronary artery disease: A meta-analysis of randomized controlled trials
Atherosclerosis 2014; 235(1): 31.

1
 
Folate Fortification and Supplementation Do Not Provide Vascular Health Benefits in Type 1 Diabetes
The Journal of Pediatrics 2013; (): .

2
 

How to Cite this Article
Pubmed Style

Alian Z, Hashemipour M, Dehkordi EH, Hovsepian S, Amini M, Moadab MH, Javanmard SH. The Effects of Folic Acid on Markers of Endothelial Function in Patients with Type 1 Diabetes Mellitus. Med Arh. 2012; 66(1): 12-15. doi:10.5455/medarh.2012.66.12-15



Web Style

Alian Z, Hashemipour M, Dehkordi EH, Hovsepian S, Amini M, Moadab MH, Javanmard SH. The Effects of Folic Acid on Markers of Endothelial Function in Patients with Type 1 Diabetes Mellitus. www.scopemed.org/?mno=16916 [Access: December 19, 2014]. doi:10.5455/medarh.2012.66.12-15



AMA (American Medical Association) Style

Alian Z, Hashemipour M, Dehkordi EH, Hovsepian S, Amini M, Moadab MH, Javanmard SH. The Effects of Folic Acid on Markers of Endothelial Function in Patients with Type 1 Diabetes Mellitus. Med Arh. 2012; 66(1): 12-15. doi:10.5455/medarh.2012.66.12-15



Vancouver/ICMJE Style

Alian Z, Hashemipour M, Dehkordi EH, Hovsepian S, Amini M, Moadab MH, Javanmard SH. The Effects of Folic Acid on Markers of Endothelial Function in Patients with Type 1 Diabetes Mellitus. Med Arh. (2012), [cited December 19, 2014]; 66(1): 12-15. doi:10.5455/medarh.2012.66.12-15



Harvard Style

Alian, Z., Hashemipour, M., Dehkordi, E. H., Hovsepian, S., Amini, M., Moadab, M. H. & Javanmard, S. H. (2012) The Effects of Folic Acid on Markers of Endothelial Function in Patients with Type 1 Diabetes Mellitus. Med Arh, 66 (1), 12-15. doi:10.5455/medarh.2012.66.12-15



Turabian Style

Alian, Zahra, Mahin Hashemipour, Elham Hashemi Dehkordi, Silva Hovsepian, Massoud Amini, Mohammad Hassan Moadab, and Shaghayegh Haghjooy Javanmard. 2012. The Effects of Folic Acid on Markers of Endothelial Function in Patients with Type 1 Diabetes Mellitus. Medical Archives, 66 (1), 12-15. doi:10.5455/medarh.2012.66.12-15



Chicago Style

Alian, Zahra, Mahin Hashemipour, Elham Hashemi Dehkordi, Silva Hovsepian, Massoud Amini, Mohammad Hassan Moadab, and Shaghayegh Haghjooy Javanmard. "The Effects of Folic Acid on Markers of Endothelial Function in Patients with Type 1 Diabetes Mellitus." Medical Archives 66 (2012), 12-15. doi:10.5455/medarh.2012.66.12-15



MLA (The Modern Language Association) Style

Alian, Zahra, Mahin Hashemipour, Elham Hashemi Dehkordi, Silva Hovsepian, Massoud Amini, Mohammad Hassan Moadab, and Shaghayegh Haghjooy Javanmard. "The Effects of Folic Acid on Markers of Endothelial Function in Patients with Type 1 Diabetes Mellitus." Medical Archives 66.1 (2012), 12-15. Print. doi:10.5455/medarh.2012.66.12-15



APA (American Psychological Association) Style

Alian, Z., Hashemipour, M., Dehkordi, E. H., Hovsepian, S., Amini, M., Moadab, M. H. & Javanmard, S. H. (2012) The Effects of Folic Acid on Markers of Endothelial Function in Patients with Type 1 Diabetes Mellitus. Medical Archives, 66 (1), 12-15. doi:10.5455/medarh.2012.66.12-15



Submit your manuscript
Register
Abstracting & Indexing
Instructions for Authors
Editorial Board
Aims & Scope
About this Journal
Sign up for TOC

ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Zahra Alian
Articles by Mahin Hashemipour
Articles by Elham Hashemi Dehkordi
Articles by Silva Hovsepian
Articles by Massoud Amini
Articles by Mohammad Hassan Moadab
Articles by Shaghayegh Haghjooy Javanmard
on IndexScholar Fulltext
on Google
on Google Scholar
Article Statistics
 Viewed: 1742
Downloaded: 387
Cited: 2




 




» For Authors




Become Reviewer


» Login Area






Follow ScopeMed on Twitter

ScopeMed Home
Job Opportunities/Service Offers
About ScopeMed
Terms & Conditions
Privacy Policy
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Service of SAGEYA Publishing for Scientific Publications. Copyright © ScopeMed® International Medical Journal Management and Indexing System.