Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article



Research of antioxidant properties of theophyllinyl-7-acetic acid derivatives

Katherine Aleksandrova, Igor Belenichev, Alexander Shkoda, Sergey Levich, Darja Yurchenko, Nina Buchtiyarova.

Abstract
Objective: Accumulation of reactive oxygen species and nitric oxide (NO) derivatives in the cell exerts damaging effects on its constituents, such as carbohydrates, proteins, lipids, and nucleic acids. These processes has been determined to play a significant role as a nonspecific pathogenetic mechanism in development of multiple disease states, such as atherosclerosis, ischemic stroke, diabetes, etc. The search for antioxidant compounds capable of interrupting the pathological biochemical processes at various steps of oxidative and nitrosative stress development, and thus exerting prophylactic and therapeutic effects, is a priority for medical and pharmaceutical sciences. In this article we investigated the effects of newly synthesized esters, hydrazides and hydrazones of theophyllinyl-7-acetic acid on late markers of oxidative and nitrosative stresses.
Methods: Investigation of antioxidant properties of xanthine derivatives was carried out using following in vitro methods: inhibition of the NO• radical, inhibition of oxidative modification of proteins, and initiation of lipid peroxidation
Results: Hydrazides and benzylidene-hydrazides of theophyllinyl-7-acetic acid showed more pronounced antioxidant properties than esters. The most active compounds among tested theophyllinyl-7-acetic acid derivatives were hydrazide and (1-phenylethyliden)hydrazide of (8-N-benzylaminotheophyllinyl-7)acetic acid.
Conclusions: In vitro studies of 23 derivatives of theophyllinyl-7-acetic acid have been shown that almost all compounds exhibit antioxidant properties. The obtained results also helped us to establish some patterns of structure-activity relationship.

Key words: Esters; Hydrazides; Theophyllinyl-7-acetic acid; Spectroscopy


Full text links

Share this Article




ScopeMed Home
Follow ScopeMed on Twitter
Article Tools
Job Opportunities/Service Offers
eJPort Journal Hosting
About ScopeMed
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons