Comparison of the efficacy of Clove (Syzygium aromaticum) oil with pioglitazone on dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycemia in albino rats
Chandralekha Netharakere, Nagendra I M Nayak, Vinodraj Kundapur, Nitasha GM Bhat, Paul Mathai, Dasaraju Rajesh, Thotahalli K Chethan, Manisha Ojha.
Abstract Objective: To evaluate the efficacy of clove oil with pioglitazone on dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycemia in albino rats. Materials and Methods: There were 4 groups of 6 rats each. First group received dexamethasone alone in a dose of 8mg/kg intraperitoneally for 6 days to induce metabolic changes and considered as dexamethasone control. Second group received clove oil orally 6days before dexamethasone and 6 days during dexamethasone administration. Third group received pioglitazone 45mg/kg orally 6 days before dexamethasone and 6 days during dexamethasone administration. Fourth group did not receive any medication and was considered as normal control. Fasting blood sugar, lipid profile, blood sugar 2 hours after glucose load, liver weight, liver volume were recorded and histopathological analysis was done. Results: The effects of clove oil were compared with that of pioglitazone. Dexamethasone caused hepatomegaly, dyslipidemia and hyperglycemia. Both pioglitazone and clove oil significantly reduced hepatomegaly, dyslipidemia and hyperglycemia (P< 0.01). Reduction of blood sugar levels after glucose load was significant with pioglitazone in comparison to clove oil (P< 0.01). Conclusion: Clove oil has comparable efficacy to pioglitazone in dexamethasone induced hepatomegaly, dyslipidemia and fasting hyperglycemia.