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Vet World. 2010; 3(8): 390-392


Heterohybridoma for the production of non murine monoclonal antibodies

Kh.Victoria Chanu and M. Ayub Ali.

Abstract
Hybridoma technology described by kohler and Milstein produce only mouse immunoglobulins.
Such immunoglobulins have limited use due to its negative side effects such as the recipient’s
immune response. The production of a non murine monoclonal antibody to combat the problems of
murine monoclonal antibody is again difficult due to the lack of a suitable myeloma cell line.
Heterohybridoma formed by the fusion of lymphocyte of one species with the myeloma cell of a
different species is the solution, which can be used for the production of non murine monoclonal
antibodies.

Key words: heterohybridoma, non-murine, lymphocytes, myeloma cell, monoclonal antibodies



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