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Vet World. 2010; 3(9): 417-420

Influence of different types of bedding materials on immune response and serum biochemical profile of caged mice

Vijayakumar . R, R.Samanta, A.K.Samanta, R. Guria and S. Joardar.

Contact bedding material is an important environmental factor and welfare creator for laboratory mice. It can
alter important physiological process and create potential chance for experimental variation which puts hurdle
for comparability. The present experiment was conducted to assess the possible impact of different types of
bedding material viz CPS, NWS and PH with fifty one albino mice for a period of fifteen weeks in Laboratory
Animal Facility. It was observed that local immunity in mice was enhanced in NWS. During in vitro immune
assays, mice from NWS showed higher OD value for reactive oxygen radical, produced more NO2 and higher
stimulation index i.e. 0.71 0.01, 30.67 0.88 μM and 7.90 0.17, respectively than PH (0.23 0.01, 17.0
1.15 μM and 6.33 0.21) and CPS (0.33 0.03, 15.67 1.20 μM and 6.46 0.27). There was no influence of
bedding type on systemic response. Reduced glutathione value in liver was higher in NWS than PH and CPS
i.e. 8.54 0.2, 7.09 0.18 and 6.96 0.14 μmole/ gm of tissue. But heart reduced glutathione showed no
variation among different types of bedding materials. Serum analysis showed significantly (p

Key words: Contact bedding, Reduced glutathione, Immune response, Mice

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