The present study was systematically undertaken to assess the antihyperglycemic, antihyperlipidemic and antioxidant activity of the methanolic (ZRM) and aqueous (ZRA) extracts of Zanthoxylum Rhetsa (Roxb.) bark. The hypoglycemic effect was evaluated in normal rats by oral glucose tolerance test (OGTT) and oral sucrose tolerance test (OSTT) by comparing with the standard. Streptozotocin (STZ) was used to induce diabetes in rats. The study also included tolerance of oral glucose, estimation of serum insulin and insulin tolerance in diabetic rats. Lipid profile, in vivo, in vitro antioxidant activity and histopathological study were performed to support antihyperglycemic activity of title plant. OGTT performed in normoglycemic rats showed that ZRA (500mg/kg) and ZRM (500mg/kg) caused 25.03% and 26.57% reduction (P
Zanthoxylum Rhetsa (Roxb.), Streptozotocin, 2, 2-diphenyl-1-picrylhydrazyl, Serum glucose, Hyperglycemia.