Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Research

J Clin Exp Res. 2014; 2(3): 158-162

Comparative study of oral and trans nasal midazolam as a sedative premedication in paediatric patients

Dipak L. Raval, Tahir S. Gunga.

Background: Premedication in pediatric patient before induction of anaesthesia is of vital importance. Midazolam is a benzodiazepine which produces anxiolytic, amnestic, hypnotic and skeletal muscle relaxant effects. Objectives: To evaluate the safety, acceptability, level of sedation and ease of administration of midazolam by using oral and trans nasal route as a sedative premedication in paediatric patient. Materials and Methods: Sixty paediatric patients of ASA grade I or II, aged 2-10 years, undergoing elective surgery were randomly divided into two groups. Group I received oral syrup midazolam 0.5mg/kg and Group II received nasal spray midazolam 0.25mg/kg. Demographic profile, response to drug administration, level of sedation, separation from parents, venipuncture, induction and postoperative recovery scores were noted and statistically analyzed. Results: The study shows that children receiving oral midazolam has better acceptability (group I, 76.66%) than when administered through intranasal route (group II, 53.33%). Sedation score were better at 20 min. in intranasal group (3.06 versus 2.96) than oral group. Post anesthesia recovery scores were similar in both groups. Conclusion: On the basis of our study, we concluded that oral syrup midazolam has better acceptability while intranasal spray midazolam has slightly faster onset without prolonging recovery from anesthesia.

Key words: Intranasal spray midazolam, oral syrup midazolam, pediatric patients, preanaesthetic sedation

Full text links

Share this Article

ScopeMed Home
Follow ScopeMed on Twitter
Article Tools
Job Opportunities/Service Offers
eJPort Journal Hosting
About ScopeMed
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons