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Review Article

Use of Modafinil in Psychiatric Disorders

Mehmet Hanifi Kokaçya, Ümit Sertan Çöpoğlu, Musa Şahpolat, Mustafa Arı.

Modafinil, is a psychostimulant drug with neurochemical and behavourial effects, distinct from those of amphetamine. It is used to treat patients with narcolepsy and other excessive sleepiness. Modafinil has dopaminergic, noradrenergic, histaminergic, glutamergic, serotonergic and GABAergic interactions. It is also shown that modafinil has neuroprotective effects via antioxidative mechanisms. Besides modafinil shows initial promise for a variety of off-label indications in psychiatry, including bipolar disorder, attention-deficit/hyperactivity disorder, and schizophrenia . The aim of this article is to review the literature on clinical use of modafinil in psychiatric disorders.

Key words: Modafinil, psychiatric disorders, adjunctive treatment

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