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Do Vitamin B12 Levels Need to be Evaluated in FMF Cases Having Long Term Colchicine Treatment?

Sare G. Akyuz, Muferet Erguven, Oznur Y. Hamzah.

Abstract
Objective: Colchicine used in the treatment of FMF inhibits absorption of Vitamin B12. To evaluate serum vitamin B12 levels in cases with Familial Mediterranean Fever (FMF) receiving long term colchicine therapy.
Method: Serum vitamin B12 and folic acid levels, and full blood count of 70 patients with FMF that received more than 5 years of colchicine therapy were evaluated. The results were compared with 80 patients that received less than 5 years of colchicine therapy and 70 healthy children.
Results: Mean age of the patient group was 15.5±2.45 years; and the mean age of the patients that received less than 5 years of colchicine therapy was 10.24±4.02 years. Mean vitamin B12 level of the patients that received more than 5 years of colchicine therapy (208.37±40.57 pg/ml) was significantly lower than the patients that received less than 5 years of colchicine therapy (390.77±124.19) and the control group (478.31±135.76) (p=0.0001, p

Key words: Colchicine, vitamin B12, anemia


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