Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Research

J Clin Exp Res. 2015; 3(1): 174-176

Sources of activator calcium in angiotensin II induced contractions of isolated frog aorta

Maganlal V. Gajera, Bharat K. Shah.

Contractile responses of isolated frog aortic strips to angiotensin II (A II) were not affected by concentration of verapamil that inhibited responses to potassium chloride. Inhibition of responses to both agonists was observed in the presence of manganese chloride. Preparations fully contracted with potassium chloride responded to A II to the same extent as control. A II responses persisted (though significantly reduced) even after 2 hr perfusion in calcium free solution. The results indicate mobilization of both cellular and extracellular calcium pools in A II induced contractions. Receptor operated channels (ROC) appear to be mediating transmembrane influx of Ca2+ during contractile process.

Key words: Activator calcium, angiotensin II, calcium free ringer, EDTA, frog aorta, manganese chloride, potassium depolarization, receptor operated channels, verapamil

Full text links

Share this Article

American Journal of Diagnostic Imaging


ScopeMed Home
Follow ScopeMed on Twitter
Article Tools
eJPort Journal Hosting
About ScopeMed
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons