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Periodical of AVICENA, d.o.o., Sarajevo
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ISSN: 0350-199X (Print)
ISSN: 1986-5961 (Online)
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Open Access

Original Research



Clinical Evaluation of Nigella Sativa Seeds for the Treatment of Hyperlipidemia: a Randomized, Placebo Controlled Clinical Trial

Ali Mohammad Sabzghabaee, Mehrnoush Dianatkhah, Nizal Sarrafzadegan, Sedigheh Asgary, Alireza Ghannadi.

Cited by (4)

Abstract
Background: Natural products are proved to play a good role as an alternative to synthetic chemicals in many clinical conditions. Hypercholesterolemia is the most important risk factor for atherosclerosis. Previous studies showed that Nigella sativa L. has both antioxidant and lipid lowering potentials. The aim of this study was to evaluate the efficacy of the seeds of Nigella sativa on the treatment of hyperlipidemia. Methods: In this randomized, placebo controlled clinical trial which was conducted in Isfahan city (Iran), 88 subjects aged ≥ 18 years with a total cholesterol concentration > 200 mg/dl were included. According to the patients` profiles number, they were randomized to receive either N. sativa capsules or the matching placebo. Each N. sativa capsule contained 50010 mg N. sativa crushed seeds, and patients had to take 2 g N. sativa per day for 4 weeks. Fasting baseline laboratory values (Fasting blood sugar, Total cholesterol, Low density lipoprotein, High density lipoprotein and Triglyceride) were obtained for all parameters on each subject prior to the start of the study and at the end of 4 weeks. Results: In our study a significant decrease was observed in the concentration of total cholesterol (4.78%), Low density lipoprotein (7.6%) and Triglyceride (16.65%), and this decrease was more significant for TG concentration. N. sativa had not any beneficial effects on Fasting blood sugar and High density lipoprotein. Conclusion: According to the results of our present study it seems that N. sativa may have some beneficial therapeutic effects in the treatment of hyperlipidemia. However, further investigations with a larger sample size are necessary.

Key words: Nigella sativa, Hyperlipidemia, Clinical Trial, Ethnopharmacology.



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This Article Cited By the following articles

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ISRN Pharmacology 2014; 2014(): 1.

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2
 
Endothelium-Independent Vasorelaxant Effects of Hydroalcoholic Extract from Nigella sativa Seed in Rat Aorta: The Roles of Ca2+ and K+ Channels
BioMed Research International 2014; 2014(): 1.

3
 
Trends in publication of evidence-based Traditional Iranian medicine in endocrinology and metabolic disorders
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4
 

How to Cite this Article
Pubmed Style

Sabzghabaee AM, Dianatkhah M, Sarrafzadegan N, Asgary S, Ghannadi A. Clinical Evaluation of Nigella Sativa Seeds for the Treatment of Hyperlipidemia: a Randomized, Placebo Controlled Clinical Trial. Med Arh. 2012; 66(3): 198-200. doi:10.5455/medarh.2012.66.198-200



Web Style

Sabzghabaee AM, Dianatkhah M, Sarrafzadegan N, Asgary S, Ghannadi A. Clinical Evaluation of Nigella Sativa Seeds for the Treatment of Hyperlipidemia: a Randomized, Placebo Controlled Clinical Trial. www.scopemed.org/?mno=19817 [Access: November 25, 2014]. doi:10.5455/medarh.2012.66.198-200



AMA (American Medical Association) Style

Sabzghabaee AM, Dianatkhah M, Sarrafzadegan N, Asgary S, Ghannadi A. Clinical Evaluation of Nigella Sativa Seeds for the Treatment of Hyperlipidemia: a Randomized, Placebo Controlled Clinical Trial. Med Arh. 2012; 66(3): 198-200. doi:10.5455/medarh.2012.66.198-200



Vancouver/ICMJE Style

Sabzghabaee AM, Dianatkhah M, Sarrafzadegan N, Asgary S, Ghannadi A. Clinical Evaluation of Nigella Sativa Seeds for the Treatment of Hyperlipidemia: a Randomized, Placebo Controlled Clinical Trial. Med Arh. (2012), [cited November 25, 2014]; 66(3): 198-200. doi:10.5455/medarh.2012.66.198-200



Harvard Style

Sabzghabaee, A. M., Dianatkhah, M., Sarrafzadegan, N., Asgary, S. & Ghannadi, A. (2012) Clinical Evaluation of Nigella Sativa Seeds for the Treatment of Hyperlipidemia: a Randomized, Placebo Controlled Clinical Trial. Med Arh, 66 (3), 198-200. doi:10.5455/medarh.2012.66.198-200



Turabian Style

Sabzghabaee, Ali Mohammad, Mehrnoush Dianatkhah, Nizal Sarrafzadegan, Sedigheh Asgary, and Alireza Ghannadi. 2012. Clinical Evaluation of Nigella Sativa Seeds for the Treatment of Hyperlipidemia: a Randomized, Placebo Controlled Clinical Trial. Medical Archives, 66 (3), 198-200. doi:10.5455/medarh.2012.66.198-200



Chicago Style

Sabzghabaee, Ali Mohammad, Mehrnoush Dianatkhah, Nizal Sarrafzadegan, Sedigheh Asgary, and Alireza Ghannadi. "Clinical Evaluation of Nigella Sativa Seeds for the Treatment of Hyperlipidemia: a Randomized, Placebo Controlled Clinical Trial." Medical Archives 66 (2012), 198-200. doi:10.5455/medarh.2012.66.198-200



MLA (The Modern Language Association) Style

Sabzghabaee, Ali Mohammad, Mehrnoush Dianatkhah, Nizal Sarrafzadegan, Sedigheh Asgary, and Alireza Ghannadi. "Clinical Evaluation of Nigella Sativa Seeds for the Treatment of Hyperlipidemia: a Randomized, Placebo Controlled Clinical Trial." Medical Archives 66.3 (2012), 198-200. Print. doi:10.5455/medarh.2012.66.198-200



APA (American Psychological Association) Style

Sabzghabaee, A. M., Dianatkhah, M., Sarrafzadegan, N., Asgary, S. & Ghannadi, A. (2012) Clinical Evaluation of Nigella Sativa Seeds for the Treatment of Hyperlipidemia: a Randomized, Placebo Controlled Clinical Trial. Medical Archives, 66 (3), 198-200. doi:10.5455/medarh.2012.66.198-200



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