Abstract
Background: Oral leukoplakia, being a potentially malignant disorder, has been noted to be associated with tobacco usage in various forms and was treated by both surgical and nonsurgical modalities, but its treatment outcome is not the same in every case.

Objective: This study aims to determine various sites involved in association with different types of habits, their frequency, duration, and also outcome of the treatment provided for oral leukoplakia patients pertaining to our geographical area.

Materials and Methods: The data were retrieved from the archives of the department of oral medicine and radiology and it include information about patients—demographics, associated habits, site of the lesion, histopathological report, and the treatment provided.

Result: Of the 151 clinically and histopathologically diagnosed oral leukoplakia cases recorded within 6 months of follow-up, the most commonly involved site for leukoplakia was observed to be buccal mucosa with its peak prevalence in the fifth and sixth decades, and those involving tongue and floor of the mouth showed higher risk for malignant transformation. Treatment was provided according to the site and size of the lesion, with diffused large ones treated with systemic antioxidants alone, well-circumscribed small ones treated surgically aided with antioxidants, and for those with super-added fungal infection, topical antifungal medication is provided along with systemic antioxidants, which had showed satisfactory results.

Conclusion: Early identification and prompt treatment along with patient self-determination to quit the habit are necessary to decrease the prevalence of these lesions and diminish their chances of transformation into malignancy, which will recuperate the quality of life of an individual.

Key words: Oral leukoplakia, tobacco, potentially malignant disorders