Abstract
In a prospective cross sectional study conducted at Kanchi Kamakoti Childs Trust hospital, a major private tertiary care hospital for children in Chennai, India during the period October 2013 to September 2014. 105 cases were diagnosed as typhoid with their blood culture yielding the growth of Salmonella typhi. Those children were followed with drug sensitivity pattern and the trend of sensitivity was compared. Regarding antibiotic sensitivity pattern, 97.1% were Nalidixic acid resistant, 4.76% were ampicillin resistant, 1.9% were ciprofloxacin resistant. 0.95% contributed to multidrug resistant typhoid (resistant to chloramphenicol, ampicillin, and co-trimoxazole). Regarding Nalidixic acid resistant strains in our hospital, the occurrence have increased from 56% in 2006-2007 and 73% in 2007-2008 to 97.1% in 2013-2014. This study had 102 patients with Nalidixic acid resistant strains (97.1%), P value was significant (