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Original Article

J Liaquat Uni Med Health Sci. 2012; 11(2): 105-108


Effect of Methanol Extract of Ajwain (Trachyspermum Ammi L) on Blood Coagulation in Rats

Muhammad Ali Rajput, Rafeeq Alam Khan, Nasreen Qazi and Zeeshan Feroz.

Abstract
OBJECTIVE: To assess the effect of methanol extract of Ajwain on coagulation parameters PT
and aPTT and to determine usefulness.
DESIGN: This comparative study was conducted in the Department of Pharmacology, Faculty of
Pharmacy, University of Karachi, Pakistan.
METHODS: Antithrombotic tests PT and aPTT were conducted after multiple dosing of Ajwain
on rats using standard kits and reagents, which were performed on Humaclot duo Germany.
The data was subjected to analysis by taking mean and standard error to the mean using student
T- test.
RESULTS: The results revealed that Ajwain extract did not show any significant effect on aPTT
whereas increase in PT was highly significant (P < 0.001).
CONCLUSION: The results suggested that the methanol extract of Ajwain prolonged PT, similar
to that of Warfarin suggesting its possible effects on the extrinsic pathway, while aPTT was not
altered suggesting that it may have no effects on the intrinsic pathway.

Key words: Trachyspermum Ammi (L), Warfarin, Prothrombin time, Activated Partial thromboplastin time.



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