OBJECTIVE: To determine histological changes in my epithelial cells and ducts in breast tissue after oral administration of Aspirin.
STUDY DESIGN: Experimental Study
PLACE AND DURATION: The study was conducted at Islamic International Medical College, Rawalpindi, during 1st August 2011 - 31st October 2011.
METHODOLOGY: Twenty adult male rabbits were obtained from national institute of health. Ten rabbits were included in experimental group and 10 were used as their controls. The experimental group was given 500 mg Aspirin / 10 ml of water/day for 30 days through infant feeding tube. Day 0 was taken as day of stat of experiment. After 30 days rabbits were sacrificed and breast tissue was taken.
RESULTS: The number of myoepithelial cells was significantly more as compared to control group. The interlobular connective tissue around the ducts and alveoli was loosely arranged and cellular, whereas that surrounding the larger ducts and lobes (interlobular connective tissue) was variably dense and contained much adipose tissue.
CONCLUSION: Aspirin influences normal histology of breast and myoepithelial cells respond to oral intake of aspirin.
Aspirin, Histology, Breast, Myoepitheial Cells.