Nephrotic Syndrome as a Paraneoplastic Syndrome of Hodgkin?s Disease: Case Report
Ãzlem Elkıran*, Yılmaz Tabel*, Ãnsal Ãzgen*, Cemşit Karakurt*, GÃ¼lendam KoÃ§ak*.
Nephrotic syndrome is a known but rare paraneoplastic syndrome accompanying Hodginâs disease. Nephrotic syndrome may precede, coincide or follow the diagnosis of malignancy. Minimal change glomerular nephropathy is the most frequently observed renal lesion. The immunopathological background of this entity is unknown. But, it is thought that T-cell dsyfunction leads to a secretion of cytokines which alters the permeability of the glomerular basement membrane. The clear recognition of a paraneoplastic syndrome is important, as it is often only necessary to treat the malignancy. In this report, we describe a-3-year-old boy who presented as nephrotic syndrome at 16 months prior to the diagnosis of Hodginâs disease .
Key Words:Â Paraneoplastic Syndrome, Hodgkinâs Disease