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Ann Med Res. 2010; 17(3): 169-173

The Histological Evaluation of the Testes of Rats which Applied Formaldehyde and Lavender Oil



Evren Köse*, Mustafa Sarsılmaz**, Sedat Meydan***, Hıdır Pekmez****, Durrin Özlem Dabak*****, Ahmet Kavaklı** Murat Ögetürk**




Aim: In our study, harmful effects of formaldehyde (FA) inhalation on the testes were investigated histologically. In addition, the possible protective effects of lavender oil which often used in aromatherapy, were examined against these damages.

Material-Methods: For this purpose, 21 albino-Wistar rats were used. The rats of group I was used as control group. The rats of group II were exposed FA (10 ppm/ 1hour) for 35 days. The rats of group III inhaleted lavender oil (1ml/1 hour) with FA. At the end of the experiment, all rats were sacrified and testes were removed for histological examination. In this examination, the diameters of seminiferous tubul, Leydig cells and Leydig cells with damaged nucleus were determined.

Results: When the rats were exposed to formaldehyde compared with the control group, it was determined that the diameter of tubuls and number of Leydig cells were decreased and Leydig cells with damaged nucleus were increased. And also it was seen that there were atrophic changes in the tubuls. In the group in which the lavender oil was applied with formaldehyde exposure it was determined that the histological changes of testes occured via FA exposure were improved.

Conclusion: It was shown that harmful effects of FA on testes occured via formaldehyde exposure and lavender oil have protective effects to the these damages.

Key Words: Formaldehyde, Lavender Oil, Testes, Histology, Rat

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