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Review Article

Vet World. 2010; 3(11): 523-525

Deficiency of Uridine Monophosphate Synthase : A Recessive Disorder in Holstein Friesian Cattle

Vijay Kumar, Ramesh Kumar Singh, Ashwani Sharma.

The present review is to summarise findings on one of the most important recessive hereditary disorder deficiency of uridine monophosphate synthase (DUMPS) in cattle. It is a disease of Holstein cattle characterized by lowered blood activity of enzyme uridine monophosphate synthase (UMPS). DUMPS leads to embryonic death in early stage of pregnancy. So some serious reproductive problems take place in dairy herds. Several investigations were carried out in different countries. No carrier animals were found among
Holstein populations in Poland, Iran, India and Turkey, but the mutant allele was detected in the studies carried out in U.S.A. and Argentina. DUMPS of Holstein cattle is a component of the hypothesized multi-component complex. It is transmitted as an autosomal recessive trait. A carrier-normal mating results in one-half carriers, regardless of sex. Embryo homozygous for DUMPS die early in gestation and do not survive to the birth. The embryos often are resorbed during the first two-month of gestation, leading to more services per calving and longer than normal calving intervals (Shanke and Robinson, 1989). The only way to avoid economic losses is
an early detection of DUMPS carriers. The use of PCR based molecular technologies promises quick detection of carriers enables their culling therefore, controlling and preventing the spread of DUMPS in the population.

Key words: Autosomal recessive disorder, DUMPS, Holstein Friesian, Pyrimidine nucleotide, Orotic acid

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