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Vet World. 2010; 3(7): 323-325

Effect of induced Hypothyroidism on plasma cholesterol and bilirubin in Marwari Sheep

Barkha Gupta, Anil Moolchandani, Meenaxi Sareen.

Hypothyroidism was induced in Marwari adult sheep (9 rams) by thiourea feeding (@ 50 mg/kg body weight). The blood samples were collected and analysed on 0 (control), 3rd, 5th and 7th day of thiourea feeding. The investigation was carried out to study the effects of induced hypothyroidism on plasma cholesterol and billirubin in Marwari sheep. Plasma cholesterol showed a non-significant (P > 0.05) effect of induced hypothyroidism however, it increased gradually with the subsequent phases of induced hypothyroidism. The analysis of variance (ANOVA) indicated a significant (P?0.01) increase in plasma bilirubin concentration during different phases of induced hypothyroidism in our study. Thus, Hypercholesterolemia and Hyperbilirubinemia are the salient clinical and biochemical features of induced hypothyroidism.

Key words: Hypothyroidism, Sheep, Cholesterol, Plasma

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