Home    eJManager.com Add Your Journal   |    Follow on Twitter   |    Subscribe to List

Directory for Medical Articles

Open Access

Original Article

Airway antioxidant capacity and pH in chronic obstructive pulmonary disease

Wei Lee, Hsien Loo, Paul S. Thomas.

Oxidant-antioxidant imbalance is implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Exhaled breath condensate (EBC) is a novel and non-invasive method of assessing the redox status of the local airway in COPD subjects. It was hypothesized that COPD patients have less antioxidant capacity in their local airway as compared to the control subjects. The method involved collecting EBC from control and COPD patients (stable and during an exacerbation). Concentrations of EBC antioxidants, namely Trolox-equivalent antioxidant capacity (TEAC), bilirubin, urate and ascorbate, were analyzed using ELISA and high performance liquid chromatography. The mean TEAC level in the stable COPD group was significantly reduced compared to the ex-smokers & smokers. The COPD group during an exacerbation had a mean bilirubin level of 0.22 ± 0.04 mg/dl, which was significantly lower than the stable COPD group (0.35 ± 0.01 mg/dl), and the non-smoking group (0.35 ± 0.02 mg/dl). Urate and ascorbic acid were undetectable. In conclusion, COPD patients are likely to have increased oxidative stress and reduced antioxidant capacity in their local airways.

Key words: Bilirubin; Exhaled breath condensate; pH; Trolox

Full text links

Share this Article

ScopeMed Home
Follow ScopeMed on Twitter
Article Tools
Job Opportunities/Service Offers
eJManager OJMS
eJPort Journal Hosting
About ScopeMed
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Service of eJManager LLC Publishing for Scientific Publications. Copyright © ScopeMedź Information Services.
Scopemed Buttons