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Comparative evaluation of low dose-vaginal misoprostol and intra-cervical dinoprostone for cervical ripening and induction of labour in term pregnancy

Priyanka Sharma, Sujata Sharma, Harbhajan Kaur Shergill.

Background: Induction of labour is one of the most common obstetric interventions worldwide. The study was conducted to compare the efficacy and safety of 25g (low dose) vaginal Misoprostol with intracervical Dinoprostone for cervical ripening and induction of labour in term pregnancy.
Methods: The study was conducted on 200 eligible term gravidas admitted for the purpose of labour induction. Subjects were randomly allotted to two groups. Group A (100 patients) received 25g vaginal Misoprostol 6 hourly, while Group B (100 patients) received intracervical Dinoprostone 6 hourly for a maximum of 3 doses each, for cervical ripening and induction of labour. The main outcomes analysed were the induction-to-vaginal delivery interval, number of vaginal deliveries within 24 hours, dose of prostaglandin required, need for oxytocin augmentation and incidence of operative or caesarean delivery and rates of hyper stimulation, maternal complications and neonatal outcome.
Results: Misoprostol use was associated with shorter induction-to-vaginal delivery interval (1165.60+306.28 minutes v/s 1369.80+286.96 minutes, p=

Key words: Cervical ripening, Dinoprostone, Labour induction, Low- dose misoprostol

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Archives of Clinical and Experimental Surgery (ACES)


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