Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article

PAFMJ. 2016; 66(2): 180-184


ESTABLISHMENT AND COMPARISON OF NEPHROTOXICITY ASSOCIATED WITH THE USE OF VARIOUS DOSES OF COLISTIN IN RABBITS

Zarafshan Bader, Akbar Waheed, Rizwan Hashim.

Abstract
Objective: This study was designed to assess the nephrotoxicity associated with various doses of Colistin sulfate in rabbits.
Study Design: Laboratory based randomized controlled trials,
Place and Duration of Study: This study was held at Army Medical College, Rawalpindi. Study period was from 15th April till 30th April 2012.
Material and Methods: Rabbits were divided into three groups of six rabbits each. Baseline serum urea, serum creatinine and serum electrolytes were estimated. A loading dose of colistin infusion was given followed by I.M injections for six days. Rabbits were sacrificed 24 hours after the last dose and both kidneys were sent for histopathology.
Results: There was marked nephrotoxicity in high toxic group where as in low toxic group mild nephrotoxicity was evident.
Conclusion: It was established that we may safely escalate dose of colistin up to four times the currently recommended schedule to combat the threat of resistance when using it for one to two weeks.

Key words: Colistin, Colistin methanesulfonate, Nephrotoxicity.



Share this Article


Advertisement
Journal of Environmental and Occupational Science

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons