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Original Article

PAFMJ. 2016; 66(2): 216-220


DETECTION OF STAT-1 IN PATIENTS CO-INFECTED WITH HEPATITIS B AND C RESISTANT TO INTERFERON

Naveeda Manzoor, Amir Rashid, Suhail Razak, Asifa Majeed.

Abstract
Objective: Current study was designed to determine the STAT-1 in co-infected patients of hepatitis B and C resistant to interferon therapy.
Study Design: Cross-sectional analytical study.
Place and Duration of Study: Department of Biochemistry & Molecular Biology & Gastroenterology departments of various hospitals of Rawalpindi.
Material and Methods: The study included 15 co-infected patients of hepatitis B and C resistant to interferon therapy and 15 healthy individuals as control.
Methodology: Detection of STAT-1 was done by conventional PCR technique.
Results: Sixty seven percent of the patients were expressing STAT-1 in their blood while 33% of the patients did not have STAT-1. Controls showed 57% detection of STAT-1 and 43% did not exhibit STAT-1. Mean age of the patients and controls was 35.90 8.95.Comparison between patients and controls was done by chi square test. Fisher exact probability value obtained was 0.287 which was not significant.
Conclusion: Patients suffering from hepatitis B and C co-infection resistant to interferon therapy revealed higher detection of STAT-1 which indicate greater liver damage, fibrosis and an extensive and severer disease course in co-infection

Key words: Co-infection, HBV, HCV, Interferon, STAT-1.



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