Journal Management System
ScopeMed is an
Online Journal/Article Management system
that can enable all of the operations of
the editorial functions of a journal.
Home  |   Add your Journal  |   Features  |   Job Opportunities/Service Offers  |   Journal List
Author Login | Reviewer Login | Editor Login
Search  

Medical Archives
Periodical of AVICENA, d.o.o., Sarajevo
Journal Home Page
ISSN: 0350-199X (Print)
ISSN: 1986-5961 (Online)
Language: [ English ]  
News / Announcements

  » Volume 68, Issue 3
      pp. 156-222
  » Volume 68, Issue 2
      pp. 76-146
  » Volume 68, Issue 1
      pp. 4-70

 

Open Access

Original Research



Role of Early Viral Infections in Development of Multiple Sclerosis

Jasminka Djelilovic - Vranic, Azra Alajbegovic.

Abstract
Introduction: Multiple sclerosis is a chronic inflammatory, autoimmune, demyelinating, disease but also degeneration of axons, with mainly progressive course, causing greater or lesser degree of disability. In addition to genetic predisposition the environmental factors, with particular importance of early viral infection, have an essential role in the development of MS. These are called long-acting viruses that remain hidden in the body for years by encouraging latent immunological changes in the body, eventually resulting in autoimmune demyelination and the appearance of disease symptoms, which confirms the high titer of antibodies to certain viruses in patients with the MS. To first of all herpes simplex virus, Epstein Barr virus, cytomegalovirus and rubella virus. Goal: Goal of this study is to analyze the incidence of early infection with rubella virus, herpes simplex, cytomegalovirus and Epstein-Barr, in MS patients using titers of IgG and IgM antibodies. Material and methods: The study included patients treated at the Neurology Clinic in Sarajevo, with a diagnosis of multiple sclerosis (newly discovered) in the period January 2009 - December 2011. To all patients beside history and neurological examination and tests to confirm the MS (brain MRI, evoked potentials and CSF examination) made ​​serological tests for viruses, HSV, Rubella virus, cytomegalovirus and Ebstain-Barr’s virus, with reference to the previous parameters (old) and new viral infection. Results: In this period there were 118 newly diagnosed multiple sclerosis from which 69.5% (82) female and 30.5% (36) male patients aged 23-56 years. IgG antibodies to herpes simplex virus was positive in 93.2% (110 patients) (72 F and 38 M and IgM only in 0.84% (1 patient). Ig G in Cytomegalovirus was positive in 86.44% (102 subjects, 71 females and 31 males), while IgM was negative in whole sample. IgG Rubella virus was positive in 61.01% (72 patients, 52 F and 20 M) and IgM was negative in all, while IgG in Ebstain -Barr’s virus was positive in 83% (98 patients). Conclusion. Early infection by herpes simplex virus, cytomegalovirus, Epstein-Barr and Rubella is present in patients with multiple sclerosis in a significant number so the conclusions is the fact that in the development of multiple sclerosis an important role early exposure to these viruses.

Key words: early viral infection, multiple sclerosis


ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Jasminka Djelilovic - Vranic
Articles by Azra Alajbegovic
on IndexScholar Fulltext
on Google
on Google Scholar
Article Statistics
 Viewed: 902
Downloaded: 226
(Last 7 Days: 3)
Cited: 0
Emailed: 0

REFERENCES
1. Kantardžić Dž. i sar. Klinička neurologija. Svjetlost, Sarajevo, 2001.

2. Reiber H, Ungefehr S, Jacobi C. The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis, 12 april 2011.

3. World Health Organizations: Atlas Multiple sclerosis resources in the world, 2008.

4. Zvizdić Š. Opća medicinska virusologija, univerzitetski udžbenik, Sarajevo, 2002.

5. Alvarez-Lafuente R, García-Montojo M, De Las Heras V, Domínguez-Mozo MI, Bartolome M, Benito-Martin MS, Arroyo R. Herpes viruses and human endogenous retroviral sequences in the cerebrospinal fluid of multiple sclerosis patients, 2008 Jun;14; 595-601.

6. A Nationwide, Population-Based Study Jiunn-Horng Kang1, Jau-Jiuan Sheu,Senyeong Kao and Herng-Ching Lin. Increased Risk of Multiple Sclerosis Following Herpes Zoster, The Journal of infectious diseases. 07/2011; 204(2): 188-192.

7. Lowry F. Herpes Zoster Boosts Risk for Multiple Sclerosis, Published online June 7, 2011.

8. Garcia-Montojo M, De Las Heras V, Dominguez-Mozo M, Bartolome M, Garcia- Martinez MA, Arroyo R, Alvarez-Lafuente R; On behalf of the HHV-6 and Multiple Sclerosis Study Group: Human herpesvirus 6 and effectiveness of interferon beta 1b in multiple sclerosis patients, 25 april 2011.

9. Perron H, Bernard C, Bertrand JB, Lang AB, Popa I, Sanhadji K, Portoukalian J. JNeurol Sci. Endogenous retroviral genes, Herpesviruses and gender in Multiple Sclerosis. 2009 Nov 15; 286(1-2): 65-72.

10. Cassels C. Multiple Sclerosis Prevalence Increasing Faster Among Women Than Men April 24, 2007.

11. Howard M, Sellors JW, Jang D, Robinson NJ, Fearon M, Kaczorowski J, Chernesky M. Regional Distribution of Antibodies to Herpes Simplex Virus Type 1 (HSV-1) and HSV-2 in Men and Women in Ontario, Canada 2003.

12. Malkin JE, Morand P, Malvy D, Ly TD, Chanzy B, de Labareyre C, El Hasnaoui A, Hercberg S. Seroprevalence of HSV-1 and HSV-2 infection in the general French population, 2002; 78: 201-203.

13. Vyse AJ, Gay NJ, Slomka MJ, Gopal R, Gibbs T, Morgan-Capner P, Brown DW. The burden of infection with HSV-1 and HSV-2 in England and Wales: implications for the changing epidemiology of genital herpes, 2000; 76: 183-187.

14. Sotgiu S, Arru G, Mameli G, Serra C, Pugliatti M, Rosati G, Dolei A. Multiple sclerosis-associated retrovirus in early multiple sclerosis: a six-year follow-up of a Sardinian cohort, 2006 Dec; 12(6): 698-703.

15. Sever JL, Schiff GM, Bell JA, Kapikian AZ, Huebner RJ, Traub RG. Rubella: frequency of antibody among children and adults, 2009.

16. Lassmann H, Niedobitek G, Aloisi F, Middeldorp JM, The NeuroproMiSe EBV Working Group: Epstein - Barr virus in the multiple sclerosisbrain: a controversial issue - report on a focused workshop held in the Centre for Brain Research of the Medical University of Vienna, Austria, June 25, 2011.

17. Jilek S, Schluep M, Meylan P, Vingerhoets F, Guignard L, Monney A, Kleeberg J, Le Goff G, Pantaleoand G,Du Pasquier RA. Strong EBV - specific CD8+ T-cell response in patients with early multiple sclerosis, May 9, 2008.

18. Cassels C. Men and Women Equally Transmit Genetic Risk for MS to Offspring 2007.

19. Authors and Disclosures: Genetics and Natural History of Multiple Sclerosis: Genetics of Multiple Sclerosis, 2008,


How to Cite this Article
Pubmed Style

Vranic JD-, Alajbegovic A. Role of Early Viral Infections in Development of Multiple Sclerosis . Med Arh. 2012; 66(Suplement 1): 37-40. doi:10.5455/medarh.2012.66.s37-s40



Web Style

Vranic JD-, Alajbegovic A. Role of Early Viral Infections in Development of Multiple Sclerosis . www.scopemed.org/?mno=22475 [Access: July 22, 2014]. doi:10.5455/medarh.2012.66.s37-s40



AMA (American Medical Association) Style

Vranic JD-, Alajbegovic A. Role of Early Viral Infections in Development of Multiple Sclerosis . Med Arh. 2012; 66(Suplement 1): 37-40. doi:10.5455/medarh.2012.66.s37-s40



Vancouver/ICMJE Style

Vranic JD-, Alajbegovic A. Role of Early Viral Infections in Development of Multiple Sclerosis . Med Arh. (2012), [cited July 22, 2014]; 66(Suplement 1): 37-40. doi:10.5455/medarh.2012.66.s37-s40



Harvard Style

Vranic, J. D. -. & Alajbegovic, A. (2012) Role of Early Viral Infections in Development of Multiple Sclerosis . Med Arh, 66 (Suplement 1), 37-40. doi:10.5455/medarh.2012.66.s37-s40



Turabian Style

Vranic, Jasminka Djelilovic -, and Azra Alajbegovic. 2012. Role of Early Viral Infections in Development of Multiple Sclerosis . Medical Archives, 66 (Suplement 1), 37-40. doi:10.5455/medarh.2012.66.s37-s40



Chicago Style

Vranic, Jasminka Djelilovic -, and Azra Alajbegovic. "Role of Early Viral Infections in Development of Multiple Sclerosis ." Medical Archives 66 (2012), 37-40. doi:10.5455/medarh.2012.66.s37-s40



MLA (The Modern Language Association) Style

Vranic, Jasminka Djelilovic -, and Azra Alajbegovic. "Role of Early Viral Infections in Development of Multiple Sclerosis ." Medical Archives 66.Suplement 1 (2012), 37-40. Print. doi:10.5455/medarh.2012.66.s37-s40



APA (American Psychological Association) Style

Vranic, J. D. -. & Alajbegovic, A. (2012) Role of Early Viral Infections in Development of Multiple Sclerosis . Medical Archives, 66 (Suplement 1), 37-40. doi:10.5455/medarh.2012.66.s37-s40







Total Download: 163.775
(for Medical Archives)
Total Submission during last 24 hours: 263


» For Authors




Become Reviewer


» Login Area




Follow ScopeMed on Twitter

ScopeMed Home | About ScopeMed | Contact Us | Terms & Conditions | Privacy Policy
The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Service of SAGEYA Publishing for Scientific Publications. Copyright © ScopeMed® International Medical Journal Management and Indexing System.