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Immunology of Osteoporosis: A Short-Review

Volkan Subasi.

Abstract
The osteoporosis pathogenesis is multifactorial and the immune system has an important role. Free radicals and the proteins or lipids that become glycated after exposure to sugars that may be related with bone resorption and inflammation.
It is now recognized that the receptor activator of NF-κB ligand (RANKL) has a major role at the bone resorbing. The physiological receptor of the biological activity of RANKL is managed by osteoprotegerin (OPG). The balance of RANKL and OPG in physiological bone turnover may control the bone density and pathological conditions. This review aims to provide a short overview of osteoimmunology in osteoporosis.

Key words: Osteoporosis, osteoimmunology, bone


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