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RMJ. 2016; 41(4): 487-491

Nephrotoxicity in experimental rabbits and nephroprotective effect of metformin

Ayesha Janjua, Akbar Waheed, Salman Bakhtiar.

Objective: To evaluate potential role of metformin in protecting kidneys from nephrotoxicant insult.
Methods: Twenty four rabbits were randomly divided into four groups (n=6). G-1 received 1 ml isotonic saline intraperitoneally(IP) daily for 13 days. G-2 received daily gentamicin(40 mg/kg/day)IP for 13 days. G-3 received metformin salt (100 mg/kg/day) dissolved in drinking water via feeding tube for 13 days. G-4 received metformin salt (100 mg/kg/day) via feeding tube plus gentamicin(40 mg/kg/day)IP for 13 days. Blood was collected on days 0 and 14 for serum urea & creatinine estimation. All animals were sacrificed and kidneys were removed for renal histological examination.
Results: Metformin showed nephroprotective effect.
Conclusion: Metformin offers complete nephrotection when administered along with nephrotoxic dose of gentamicin. This could offer an efficacious and cheaper treatment alternative in those diabetics who also suffer from gram negative infections.

Key words: Nephrotoxicity, Nephroprotection, Renoprotection, Gentamicin, Metformin,

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