Abstract
Plasmablastic lymphoma is a rare aggressive malignancy of B cell origin. Commonly the nasal and Paranasal regions are involved in HIV positive individuals. We report a retro positive individual presenting with a swelling over the right leg. Clinical and radiological investigations suggested the swelling arising from the extensor digitorum longus (EDL). Differential diagnosis of Rhadomyosarcoma and schwanomma considered after clinico-radiological evaluation. Plasmablastic lymphoma was diagnosed after biopsy and IHC marker analysis.
Plasmablastic lymphoma though common in retro-positive patients, arising from the muscle is uncommon. An aggressive tumour of poor prognosis, delay in its diagnosis and treatment because of its uncommon location can cause rapid spread of tumour and death of patient. In our report we want to create awareness to the treating clinician and pathologist that swellings arising from uncommon site in HIV positive individual should be evaluated to rule out plasmablastic lymphoma.

Key words: HIV positive, Muscle, Plasmablastic Lymphoma