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Comparative analysis of epinastine vs olopatadine eye drops in moderate allergic conjunctivitis patients

Preet Sood, Manmohan Bhanot, Narinder Singh, Rahat Kumar.

Abstract
Background: Allergic conjunctivitis is a perennial ocular allergic disease. It is the inflammatory response of the conjunctiva to allergens such as pollen, animal dander, and other environmental allergens. The treatment consists of avoidance of the offending antigen, topical decongestants, antihistamines, mast cell stabilizers, non steroidal anti-inflammatory drugs and corticosteroids.
Olopatadine hydrochloride 0.1% ophthalmic solution (Patanol) and Epinastine hydrochloride 0.05% ophthalmic solution (Elestat) are two topical ant allergic agents.
Methods: After taking institutional ethics committee approval, total n= 62 (33, 29) patients were enrolled. Patients were randomized and divided into two study groups (1-olopatadine, 2-epinastine). After prescribing the drug therapy (day 1), patients were asked to visit at 3,7,15 day and at 1month. At every visit, slit lamp examination was done. Changes in all sign/symptoms were recorded. For the statistical testing of the data Chi-square test is used to find the association of variable. Mann Whitney -u test is applied for the statistically analysing the two group.
Results: Both the study drugs found to be equally efficacious except at few points. Only statistically marked difference was observed in papillary hyperaemia (p

Key words: Allergic conjunctivitis, Anti histaminic, Epinastine, Mast cell stabilizers, Olopatadine


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