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Propantheline induced pharmacokinetic variability in lithium bioavailability in human volunteers after co-administration with lithium and imipramine

Preet Sood, Vikram Bhandari, Narinder Singh, Jaswinder Singh.

Background: Lithium is used commonly in bipolar illness. It is co administered with many other drugs like imipramine, fluoxetine to improve the clinical efficacy of the therapy. Co administrations of other drugs like NSAIDS and GIT drugs for various ailments are also common. As this drug possesses a narrow therapeutic range, effect of other drugs on its pharmacokinetic parameters is important to achieve its therapeutic goal as well as to avoid serious adverse effect.
Methods: Total n= 30 human volunteers were enrolled in the study. After randomization subjects were divided into three study groups. Group 1 was given lithium (900mg) alone while group 2 and 3 were given lithium (900mg) and imipramine (25mg) at 0h. Group 3 patients were administered propantheline (15mg) 1 hr prior to lithium and imipramine.
Results: In group 2 (Li+Imp) treatment with imipramine produced a significant decrease in C max (p

Key words: Imipramine, Lithium, Pharmacokinetic parameters

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