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Experimental evaluation of anti-hyperglycemic and hypolipidemic effects of stevia rebaudiana, Anacardium occidentale on wistar rats

Brijesh K., Kamath M..

Abstract
Background: Diabetes mellitus, obesity, hypertension, hyperlipidaemia etc. is one of the pandemic metabolic disorder in the world, may lead to obesity, hypertension, hyperlipidaemia etc. Despite of medical advances like oral hypoglycemic agents, insulin pump, xenotransplantation and all don't provide enough control of blood sugar level to control Diabetes and its complications. Hence it is the right time for work on a new medicine, which can successfully control the blood sugar and bodily lipids and cost effective one also. In the present study an attempt is made to check the efficacy of folklore drugs with a conventional anti-diabetic compound glibenclamide.
Methods: The decoction of a drugs Stevia rebaudiana and Anacardium occidentale prepared as described in The Ayurvedic Formulary of India, wistar rats of either sex were selected randomly. Before and after values of blood glucose, triglyceride, high density lipid and total cholesterol level were taken.
Results: On analyzing the results, the study showed that the trial drug II stevia is effective and trial drug I Kajutaka is slightly effective in reducing the glucose level next to glibenclamide. The trial drug I Kajutaka showed effective in reducing the Triglyceride level followed by Stevia. The action may be due to alkaloids such as Stevioside, Rebaudioside possessed by Stevia, which may stimulate the islets of the pancreas to release Insulin. The Hypolipedimic action may be due to presence of Chemical constituents in Kajutaka leaf such as Ascorbic acid and Niacin.
Conclusions: The present experimental study is preliminary one elaborate study with larger sample size is required to come up with a more significant result.

Key words: Anacardiumoccidentale, Diabetes mellitus, Hyperglycaemia, Pancreas, Stevia rebaudiana


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